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A Transgenic Drosophila melanogaster Model To Study Human T-Lymphotropic Virus Oncoprotein Tax-1-Driven Transformation In Vivo
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
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2015 (English)In: Journal of Virology, ISSN 0022-538X, E-ISSN 1098-5514, Vol. 89, no 15, 8092-8095 p.Article in journal (Refereed) Published
Abstract [en]

Human T-cell lymphotropic virus type 1 (HTLV-1)-induced adult T-cell leukemia/lymphoma is an aggressive malignancy. HTLV-2 is genetically related to HTLV-1 but does not cause any malignant disease. HTLV-1 Tax transactivator (Tax-1) contributes to leukemogenesis via NF-kappa B. We describe transgenic Drosophila models expressing Tax in the compound eye and plasmatocytes. We demonstrate that Tax-1 but not Tax-2 induces ommatidial perturbation and increased plasmatocyte proliferation and that the eye phenotype is dependent on Kenny (IKK gamma/NEMO), thus validating this new in vivo model.

Place, publisher, year, edition, pages
2015. Vol. 89, no 15, 8092-8095 p.
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-107155DOI: 10.1128/JVI.00918-15ISI: 000358277800054PubMedID: 25995252OAI: oai:DiVA.org:umu-107155DiVA: diva2:850711
Available from: 2015-09-02 Created: 2015-08-19 Last updated: 2017-12-04Bibliographically approved

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