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The optimal number of offspring per gamete donor
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
Karolinska University Hospital, Sweden; Huddinge University Hospital, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Computer and Information Science, Statistics. Linköping University, Faculty of Arts and Sciences. Swedish Police Authority, National Forensic Centre, Linkoping, Sweden.
2015 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 94, no 9, 1022-1026 p.Article in journal (Refereed) Published
Abstract [en]

Our aim was to create a mathematical basis to calculate the risks for unintended matings of consanguineous half-siblings from a donor in a society with approximately 10 million inhabitants. The Curie-Cohen model for calculation of the risk for consanguineous mating was used. When the number of offspring per donor is limited to 10, then the model gives a yearly risk for consanguineous matings below 1%. Thus 10 offspring gives a risk for consanguineous matings of 0.9% per year, or approximately once in every 100years. The risk increases exponentially: with 15 offspring it exceeds 2% and with 25 it reaches up above 5%.

Place, publisher, year, edition, pages
Informa Healthcare / Wiley , 2015. Vol. 94, no 9, 1022-1026 p.
Keyword [en]
Number of children; donor; mathematical model; consanguinity; fertility
National Category
Clinical Medicine Mathematics
Identifiers
URN: urn:nbn:se:liu:diva-120855DOI: 10.1111/aogs.12678ISI: 000359086600017PubMedID: 26014908OAI: oai:DiVA.org:liu-120855DiVA: diva2:849473
Note

Funding Agencies|National Tissue Group for Gametes (VOG Konsceller) at the National Council for Human Organs and Tissues (Nationella Vavnadsradet) at the Swedish Association of Local Authorities and Regions (SALAR)

Available from: 2015-08-28 Created: 2015-08-28 Last updated: 2017-12-04

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Sydsjö, GunillaBladh, MarieNordgaard, Anders
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Division of Clinical SciencesFaculty of Medicine and Health SciencesDepartment of Gynaecology and Obstetrics in LinköpingStatisticsFaculty of Arts and Sciences
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