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BPI-ANCA Provides Additional Clinical Information to Anti-Pseudomonas Serology: Results from a Cohort of 117 Swedish Cystic Fibrosis Patients
Lund University, Sweden; Skåne University Hospital, Sweden.
Lund University, Sweden.
Lund University, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Nephrology.
2015 (English)In: JOURNAL OF IMMUNOLOGY RESEARCH, ISSN 2314-8861, Vol. 2015, 8- p., 947934Article in journal (Refereed) Published
Abstract [en]

Patients with cystic fibrosis (CF) colonized with Pseudomonas aeruginosa (P. aeruginosa) have worse prognosis compared with patients who are not. BPI-ANCA is an anti-neutrophil cytoplasmic antibody against BPI (bactericidal/permeability increasing protein) correlating with P. aeruginosa colonization and adverse long time prognosis. Whether it provides additional information as compared to standard anti-P. aeruginosa serology tests is not known. 117 nontransplanted CF patients at the CF centre in Lund, Sweden, were followed prospectively for ten years. Bacterial colonisation was classified according to the Leeds criteria. IgA BPI-ANCA was compared with assays for antibodies against alkaline protease (AP), Elastase (ELA), and Exotoxin A (ExoA). Lung function and patient outcome, alive, lung transplanted, or dead, were registered. BPI-ANCA showed the highest correlation with lung function impairment with an r-value of 0.44. Forty-eight of the 117 patients were chronically colonized with P. aeruginosa. Twenty of these patients experienced an adverse outcome. Receiver operator curve (ROC) analysis revealed that this could be predicted by BPI-ANCA (AUC = 0.77), (p = 0.002) to a better degree compared with serology tests. BPI-ANCA correlates better with lung function impairment and long time prognosis than anti-P. aeruginosa serology and has similar ability to identify patients with chronic P. aeruginosa.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation , 2015. Vol. 2015, 8- p., 947934
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:liu:diva-120890DOI: 10.1155/2015/947934ISI: 000359240700001PubMedID: 26273683OAI: oai:DiVA.org:liu-120890DiVA: diva2:849324
Note

Funding Agencies|Bengt Andreasson Foundation; Heart and Lung Association in Sweden

Available from: 2015-08-28 Created: 2015-08-28 Last updated: 2015-09-17

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Segelmark, Mårten
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