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Bisphosphonate associated osteomyelitis of the jaw in patients with bony exposure: prevention, a new way of thinking
Department Oral and Maxillofacial Surg, Norway.
Region Östergötland.
Department Oral and Maxillofacial Surg, Norway.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
2015 (English)In: Journal of Applied Oral Science, ISSN 1678-7757, E-ISSN 1678-7765, Vol. 23, no 3, 310-314 p.Article in journal (Refereed) Published
Abstract [en]

Objective: There is strong evidence of a link between the use of systemic bisphosphonates (BPs) and osteonecrosis of the jaw, especially in cancer patients. Among risk factors for BRONJ, tooth extraction and immune suppressive drugs seem to have significant role on bone healing. Therefore, the importance of these parameters in development of BRONJ was reviewed in this retrospective study in two maxillofacial surgery units. Material and Methods: From 2007 to 2012, 46 patients on bisphosphonate who had developed oral bony lesions participated in this study. The pharmacological exposure, comorbidities, maxillofacial findings, types of treatment and outcome data were collected from clinical and radiological records. Results: The most frequently used BP was alendronate (67%). Tooth extraction was reported in 61% of patients with BRONJ. Systemic corticosteroids were prescribed in 35 cases (76%) as an adjuvant for BP. Patients on corticosteroids had a lower probability of bony lesion healing (pless than0.05) than patients without corticosteroids. Of the 46 patients who underwent conservative treatments, only ten were completely healed (21%). Conclusions: Beside tooth extraction, corticosteroids were shown to be an implant risk factor for low rate of bone healing and hence the development of BRONJ. The outcome of conservative treatment was uncertain and this emphasizes the importance of prevention.

Place, publisher, year, edition, pages
University of S�o Paulo , 2015. Vol. 23, no 3, 310-314 p.
Keyword [en]
Bisphosphonates; Jaw; Bisphosphonate-associated osteonecrosis of the jaw; Oral health; Osteoporosis
National Category
URN: urn:nbn:se:liu:diva-120752DOI: 10.1590/1678-775720140506ISI: 000358785900010PubMedID: 26221926OAI: diva2:848303

Funding Agencies|Departments of Oral; Department of Oral and Maxillofacial Surgery at the University of Linkoping; Department of Oral and Maxillofacial Surgery at the University of Bergen

Available from: 2015-08-24 Created: 2015-08-24 Last updated: 2016-09-07

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Abtahi, Jahan
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