Meropenem-Clavulanic Acid Has High In Vitro Activity against Multidrug-Resistant Mycobacterium tuberculosis
2015 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 59, no 6, 3630-3632 p.Article in journal (Refereed) Published
We investigated the activity of meropenem-clavulanic acid (MEM-CLA) against 68 Mycobacterium tuberculosis isolates. We included predominantly multi- and extensively drug-resistant tuberculosis (MDR/XDR-TB) isolates, since the activity of MEM-CLA for resistant isolates has previously not been studied extensively. Using Middlebrook 7H10 medium, all but four isolates showed an MIC distribution of 0.125 to 2 mg/liter for MEM-CLA, below the non-species-related breakpoint for MEM of 2 mg/liter defined by EUCAST. MEM-CLA is a potential treatment option for MDR/XDR-TB.
Place, publisher, year, edition, pages
American Society for Microbiology , 2015. Vol. 59, no 6, 3630-3632 p.
IdentifiersURN: urn:nbn:se:liu:diva-120749DOI: 10.1128/AAC.00171-15ISI: 000358623200091PubMedID: 25824227OAI: oai:DiVA.org:liu-120749DiVA: diva2:848179
Funding Agencies|Swedish Society of Medicine [SLS 169241]; Marianne and Marcus Wallenberg Foundation; Swedish Heart and Lung Foundation (Oscar II Jubilee Foundation); Swedish Society of Antimicrobial Chemotherapy; Research Council of Southeast Sweden (FORSS)2015-08-242015-08-242015-08-25