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Meropenem-Clavulanic Acid Has High In Vitro Activity against Multidrug-Resistant Mycobacterium tuberculosis
Karolinska Institute, Sweden; Karolinska University Hospital Solna, Sweden.
Karolinska University Hospital, Sweden; Karolinska Institute, Sweden.
Karolinska Institute, Sweden; Karolinska University Hospital Solna, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Kalmar County Hospital, Sweden.
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2015 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 59, no 6, 3630-3632 p.Article in journal (Refereed) Published
Abstract [en]

We investigated the activity of meropenem-clavulanic acid (MEM-CLA) against 68 Mycobacterium tuberculosis isolates. We included predominantly multi- and extensively drug-resistant tuberculosis (MDR/XDR-TB) isolates, since the activity of MEM-CLA for resistant isolates has previously not been studied extensively. Using Middlebrook 7H10 medium, all but four isolates showed an MIC distribution of 0.125 to 2 mg/liter for MEM-CLA, below the non-species-related breakpoint for MEM of 2 mg/liter defined by EUCAST. MEM-CLA is a potential treatment option for MDR/XDR-TB.

Place, publisher, year, edition, pages
American Society for Microbiology , 2015. Vol. 59, no 6, 3630-3632 p.
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Clinical Medicine
URN: urn:nbn:se:liu:diva-120749DOI: 10.1128/AAC.00171-15ISI: 000358623200091PubMedID: 25824227OAI: diva2:848179

Funding Agencies|Swedish Society of Medicine [SLS 169241]; Marianne and Marcus Wallenberg Foundation; Swedish Heart and Lung Foundation (Oscar II Jubilee Foundation); Swedish Society of Antimicrobial Chemotherapy; Research Council of Southeast Sweden (FORSS)

Available from: 2015-08-24 Created: 2015-08-24 Last updated: 2015-08-25

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