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Synthesis of a clickable FDG precursor for PET in vivo imaging
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, Faculty of Science & Engineering.
2015 (English)Independent thesis Basic level (degree of Bachelor), 10,5 credits / 16 HE creditsStudent thesis
Abstract [en]

The thesis of this study describes a synthesis way to produce an alkyne equipped clickable precursor of 2-deoxy-2-fluoro-D-glucose (FDG) with a beta-configuration. This FDG-derivate is produced with a clickable link in purpose to be used in PET in vivo imaging. The product was synthesized by acetylation protection and further epoxidation on the glucose analog D-Glucal. Glycosylation occurred by electrophilic reaction of propargyl alcohol and configuration of the product was ensured during Lattrell-Dax inversion.

Place, publisher, year, edition, pages
2015. , 26 p.
Keyword [en]
Glycosylation, Epoxidation, Inversion, FDG
National Category
Natural Sciences
URN: urn:nbn:se:liu:diva-120586ISRN: LITH-IFM-G-EX--15/3047--SEOAI: diva2:848050
Subject / course
2015-06-01, E324, Linköpings Universitet, 58183 Linköping, 14:15 (Swedish)
Available from: 2015-08-26 Created: 2015-08-17 Last updated: 2015-08-26Bibliographically approved

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Synthesis of a clickable FDG precursor for PET in vivo imaging(1095 kB)111 downloads
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Säberg, Alexander
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