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Validity and responsiveness of at-home touch-screen assessments in advanced Parkinson's disease
Dalarna University, School of Technology and Business Studies, Computer Engineering.ORCID iD: 0000-0002-2372-4226
Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden.
Department of Clinical Neuroscience, Neurology, Karolinska Institutet, Stockholm, Sweden.
Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.
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2015 (English)In: IEEE journal of biomedical and health informatics, ISSN 2168-2194, E-ISSN 2168-2208, Vol. 19, no 6, 1829-1834 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to investigate if a telemetry test battery can be used to measure effects of Parkinson’s disease (PD) treatment intervention and disease progression in patients with fluctuations. Sixty-five patients diagnosed with advanced PD were recruited in an open longitudinal 36-month study; 35 treated with levodopa-carbidopa intestinal gel (LCIG) and 30 were candidates for switching from oral PD treatment to LCIG. They utilized a test battery, consisting of self-assessments of symptoms and fine motor tests (tapping and spiral drawings), four times per day in their homes during week-long test periods. The repeated measurements were summarized into an overall test score (OTS) to represent the global condition of the patient during a test period. Clinical assessments included ratings on Unified PD Rating Scale (UPDRS) and 39-item PD Questionnaire (PDQ-39) scales. In LCIG-naïve patients, mean OTS compared to baseline was significantly improved from the first test period on LCIG treatment until month 24. In LCIG-non-naïve patients, there were no significant changes in mean OTS until month 36. The OTS correlated adequately with total UPDRS (rho = 0.59) and total PDQ-39 (0.59). Responsiveness measured as effect size was 0.696 and 0.536 for OTS and UPDRS respectively. The trends of the test scores were similar to the trends of clinical rating scores but dropout rate was high. Correlations between OTS and clinical rating scales were adequate indicating that the test battery contains important elements of the information of well-established scales. The responsiveness and reproducibility were better for OTS than for total UPDRS.

Place, publisher, year, edition, pages
2015. Vol. 19, no 6, 1829-1834 p.
Keyword [en]
home assessment, levodopa infusion, Parkinson's disease, remote monitoring, telemedicine
National Category
Information Systems Computer Engineering
Research subject
Complex Systems – Microdata Analysis, FLOAT - Flexible Levodopa Optimizing Assistive Technology
URN: urn:nbn:se:du-19021DOI: 10.1109/JBHI.2015.2468088OAI: diva2:846385
FLOAT - Flexibel levodopa-optimerings och individanpassningsteknik
Knowledge Foundation
Available from: 2015-08-17 Created: 2015-08-17 Last updated: 2016-03-11Bibliographically approved

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Memedi, MevludinWestin, Jerker
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