Change search
ReferencesLink to record
Permanent link

Direct link
Tolerance to gamma radiation in the tardigrade Hypsibius dujardini from embryo to adult correlate inversely with cellular proliferation
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University.
Kristianstad University, School of Education and Environment, Avdelningen för Naturvetenskap. Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University.ORCID iD: 0000-0002-1732-0372
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University.
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University.
Show others and affiliations
2015 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 10, no 7, e0133658- p.Article in journal (Refereed) Published
Abstract [en]

Tardigrades are highly tolerant to desiccation and ionizing radiation but the mechanisms of this tolerance are not well understood. In this paper, we report studies on dose responses of adults and eggs of the tardigrade Hypsibius dujardini exposed to gamma radiation. In adults the LD50/48h for survival was estimated at ~ 4200 Gy, and doses higher than 100 Gy reduced both fertility and hatchability of laid eggs drastically. We also evaluated the effect of radiation (doses 50 Gy, 200 Gy, 500 Gy) on eggs in the early and late embryonic stage of development, and observed a reduced hatchability in the early stage, while no effect was found in the late stage of development. Survival of juveniles from irradiated eggs was highly affected by a 500 Gy dose, both in the early and the late stage. Juveniles hatched from eggs irradiated at 50 Gy and 200 Gy developed into adults and produced offspring, but their fertility was reduced compared to the controls. Finally we measured the effect of low temperature during irradiation at 4000 Gy and 4500 Gy on survival in adult tardigrades, and observed a slight delay in the expressed mortality when tardigrades were irradiated on ice. Since H.dujardini is a freshwater tardigrade with lower tolerance to desiccation compared to limno-terrestrial tardigrades, the high radiation tolerance in adults, similar to limno-terrestrial tardigrades, is unexpected and seems to challenge the idea that desiccation and radiation tolerance rely on the same molecular mechanisms. We suggest that the higher radiation tolerance in adults and late stage embryos of H.dujardini (and in other studied tardigrades) compared to early stage embryos may partly be due to limited mitotic activity, since tardigrades have a low degree of somatic cell division (eutely), and dividing cells are known tobe more sensitive to radiation.

Place, publisher, year, edition, pages
2015. Vol. 10, no 7, e0133658- p.
National Category
Natural Sciences
URN: urn:nbn:se:hkr:diva-14436DOI: 10.1371/journal.pone.0133658ISI: 000358622000116PubMedID: 26208275OAI: diva2:845621
Available from: 2015-08-12 Created: 2015-08-12 Last updated: 2015-09-02Bibliographically approved

Open Access in DiVA

fulltext(706 kB)34 downloads
File information
File name FULLTEXT01.pdfFile size 706 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Jönsson, K. Ingemar
By organisation
Avdelningen för Naturvetenskap
In the same journal
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 34 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 65 hits
ReferencesLink to record
Permanent link

Direct link