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Can Cobalt(II) and Chromium(III) Ions Released from Joint Prostheses Influence the Friction Coefficient?
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medicin)
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2015 (English)In: ACS Biomaterials Science & Engineering, Vol. 1, no 8, 617-620 p.Article in journal (Refereed) Published
Abstract [en]

Cobalt chromium molybdenum alloys (CoCr-Mo) are commonly used as articulating components in joint prostheses. In this tribocorrosive environment, wear debris and metal ionic species are released and interact with proteins, possibly resulting in protein aggregation. This study aimed to investigate whether this could have an eff ect on the friction coefficient in a typical material couple, namely CoCrMo-onpolyethylene. It was confirmed that both Co(II) and Cr(III) ions, and their combination, at concentrations relevant for the metal release situation, resulted in protein aggregation and its concomitant precipitation, which increased the friction coeffi cient. Future studies should identify the clinical importance of these findings.

Place, publisher, year, edition, pages
2015. Vol. 1, no 8, 617-620 p.
Keyword [en]
hip joint, replacement, friction, protein-metal binding, CoCrMo, alloy tribology
National Category
Other Materials Engineering Medical Materials
Research subject
Engineering Science with specialization in Materials Science
URN: urn:nbn:se:uu:diva-259426DOI: 10.1021/acsbiomaterials.5b00183ISI: 000372214100001OAI: diva2:844097
EU, FP7, Seventh Framework Programme, GA-310477Swedish Research Council, 2013-5621
Available from: 2015-08-03 Created: 2015-08-03 Last updated: 2016-04-14Bibliographically approved

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Persson, Cecilia
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