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ZnO Nanostructure-Based Intracellular Sensor
COMSATS Institute Informat Technology, Pakistan; Acromed Invest AB, Sweden.
Acromed Invest AB, Sweden.
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0001-6235-7038
2015 (English)In: Sensors, ISSN 1424-8220, Vol. 15, no 5, 11787-11804 p.Article, review/survey (Refereed) Published
Abstract [en]

Recently ZnO has attracted much interest because of its usefulness for intracellular measurements of biochemical species by using its semiconducting, electrochemical, catalytic properties and for being biosafe and biocompatible. ZnO thus has a wide range of applications in optoelectronics, intracellular nanosensors, transducers, energy conversion and medical sciences. This review relates specifically to intracellular electrochemical (glucose and free metal ion) biosensors based on functionalized zinc oxide nanowires/nanorods. For intracellular measurements, the ZnO nanowires/nanorods were grown on the tip of a borosilicate glass capillary (0.7 mu m in diameter) and functionalized with membranes or enzymes to produce intracellular selective metal ion or glucose sensors. Successful intracellular measurements were carried out using ZnO nanowires/nanorods grown on small tips for glucose and free metal ions using two types of cells, human fat cells and frog oocytes. The sensors in this study were used to detect real-time changes of metal ions and glucose across human fat cells and frog cells using changes in the electrochemical potential at the interface of the intracellular micro-environment. Such devices are helpful in explaining various intracellular processes involving ions and glucose.

Place, publisher, year, edition, pages
MDPI , 2015. Vol. 15, no 5, 11787-11804 p.
Keyword [en]
ZnO nanowire; nanorods; functionalization; intracellular measurement; glucose; metal ions; human fat cells; frog oocytes; electrochemical sensor
National Category
Electrical Engineering, Electronic Engineering, Information Engineering
URN: urn:nbn:se:liu:diva-120360DOI: 10.3390/s150511787ISI: 000357183400003PubMedID: 26007730OAI: diva2:843863
Available from: 2015-07-31 Created: 2015-07-31 Last updated: 2015-09-03

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