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Sex-specific effects of sympatric mitonuclear variation on fitness in Drosophila subobscura
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
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2015 (English)In: BMC Evolutionary Biology, ISSN 1471-2148, E-ISSN 1471-2148, Vol. 15Article in journal (Refereed) Published
Abstract [en]

Background: A number of recent studies have shown that the pattern of mitochondrial DNA variation and evolution is at odds with a neutral equilibrium model. Theory has suggested that selection on mitonuclear genotypes can act to maintain stable mitonuclear polymorphism within populations. However, this effect largely relies upon selection being either sex-specific or frequency dependent. Here, we use mitonuclear introgression lines to assess differences in a series of key life-history traits (egg-to-adult developmental time, viability, offspring sex-ratio, adult longevity and resistance to desiccation) in Drosophila subobscura fruit flies carrying one of three different sympatric mtDNA haplotypes. Results: We found functional differences between these sympatric mtDNA haplotypes, but these effects were contingent upon the nuclear genome with which they were co-expressed. Further, we demonstrate a significant mitonuclear genetic effect on adult sex ratio, as well as a sex x mtDNA x nuDNA interaction for adult longevity. Conclusions: The observed effects suggest that sex specific mitonuclear selection contributes to the maintenance of mtDNA polymorphism and to mitonuclear linkage disequilibrium in this model system.

Place, publisher, year, edition, pages
2015. Vol. 15
Keyword [en]
Mitochondria, Mitonuclear epistasis, Life history traits, Sexual dimorphism, Selection, Fruit fly
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URN: urn:nbn:se:uu:diva-259087DOI: 10.1186/s12862-015-0421-2ISI: 000357577500001PubMedID: 26156582OAI: diva2:843518
EU, European Research Council, GENCON AdG-294333Swedish Research Council, 621-2010-5266
Available from: 2015-07-29 Created: 2015-07-27 Last updated: 2016-06-27Bibliographically approved

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