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An organic electronic biomimetic neuron enables auto-regulated neuromodulation
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering. Karolinska Institute, Sweden; Karolinska Institute, Sweden.ORCID iD: 0000-0002-2799-3490
Karolinska Institute, Sweden; Karolinska Institute, Sweden.
Acreo Swedish ICT AB, Sweden.
Karolinska Institute, Sweden; Karolinska Institute, Sweden.
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2015 (English)In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 71, 359-364 p.Article in journal (Refereed) Published
Abstract [en]

Current therapies for neurological disorders are based on traditional medication and electric stimulation. Here, we present an organic electronic biomimetic neuron, with the capacity to precisely intervene with the underlying malfunctioning signalling pathway using endogenous substances. The fundamental function of neurons, defined as chemical-to-electrical-to-chemical signal transduction, is achieved by connecting enzyme-based amperometric biosensors and organic electronic ion pumps. Selective biosensors transduce chemical signals into an electric current, which regulates electrophoretic delivery of chemical substances without necessitating liquid flow. Biosensors detected neurotransmitters in physiologically relevant ranges of 5-80 mu M, showing linear response above 20 mu m with approx. 0.1 nA/mu M slope. When exceeding defined threshold concentrations, biosensor output signals, connected via custom hardware/software, activated local or distant neurotransmitter delivery from the organic electronic ion pump. Changes of 20 mu M glutamate or acetylcholine triggered diffusive delivery of acetylcholine, which activated cells via receptor-mediated signalling. This was observed in real-time by single-cell ratiometric Ca2+ imaging. The results demonstrate the potential of the organic electronic biomimetic neuron in therapies involving long-range neuronal signalling by mimicking the function of projection neurons. Alternatively, conversion of glutamate-induced descending neuromuscular signals into acetylcholine-mediated muscular activation signals may be obtained, applicable for bridging injured sites and active prosthetics. (C) 2015 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
Elsevier , 2015. Vol. 71, 359-364 p.
Keyword [en]
Neuromodulation; Organic electronic material; Controlled drug release; Neural prosthesis
National Category
Electrical Engineering, Electronic Engineering, Information Engineering
URN: urn:nbn:se:liu:diva-120203DOI: 10.1016/j.bios.2015.04.058ISI: 000356646000052PubMedID: 25932795OAI: diva2:842702

Funding Agencies|Carl Bennet AB; VINNOVA; Karolinska Institutet; Swedish Research Council; Swedish Brain Power; KAW; Royal Swedish Academy of Sciences; Onnesjo Foundation

Available from: 2015-07-21 Created: 2015-07-20 Last updated: 2015-08-06

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