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Heart failure and dementia: survival in relation to types of heart failure and different dementia disorders
Karolinska Institute, Sweden; Int Clin Research Centre, Czech Republic; St Annes University Hospital, Czech Republic.
Karolinska Institute, Sweden; Karolinska University Hospital, Sweden.
Karolinska Institute, Sweden.
Karolinska Institute, Sweden; Stockholm University, Sweden.
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2015 (English)In: European Journal of Heart Failure, ISSN 1388-9842, E-ISSN 1879-0844, Vol. 17, no 6, 612-619 p.Article in journal (Refereed) Published
Abstract [en]

AimsHeart failure (HF) and dementia frequently coexist, but little is known about their types, relationships to each other and prognosis. The aims were to (i) describe patients with HF and dementia, assess (ii) the proportion of specific dementia disorders in types of HF based on ejection fraction and (iii) the prognostic role of types of HF and dementia disorders. Methods and resultsThe Swedish Heart Failure Registry (RiksSvikt) and The Swedish Dementia Registry (SveDem) were record-linked. Associations between dementia disorders and HF types were assessed with multinomial logistic regression and survival was investigated with Kaplan-Meier analysis and multivariable Cox regression. We studied 775 patients found in both registries (55% men, mean age 82years). Ejection fraction was preserved in 38% of patients, reduced in 34%, and missing in 28%. The proportions of dementia disorders were similar across HF types. Vascular dementia was the most common dementia disorder (36%), followed by other dementias (28%), mixed dementia (20%), and Alzheimer disease (16%). Over a mean follow-up of 1.5years, 76% of patients survived 1year. We observed no significant differences in survival with regard to HF type (P=0.2) or dementia disorder (P=0.5). After adjustment for baseline covariates, neither HF types nor dementia disorders were independently associated with survival. ConclusionsHeart failure with preserved ejection fraction was the most common HF type and vascular dementia was the most common dementia disorder. The proportions of dementia disorders were similar across HF types. Neither HF types nor specific dementia disorders were associated with survival.

Place, publisher, year, edition, pages
Oxford University Press (OUP): Policy B / Wiley: 12 months , 2015. Vol. 17, no 6, 612-619 p.
Keyword [en]
Dementia; Alzheimer disease; Vascular dementia; Heart failure; Preserved ejection fraction; Reduced ejection fraction; Survival; Registry
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-120234DOI: 10.1002/ejhf.222ISI: 000356799600011PubMedID: 25581033OAI: diva2:842629

Funding Agencies|Swedish Brain Power; Swedish Association of Local Authorities and Regions; Swedish Society of Cardiology; Swedish Heart-Lung Foundation; Stockholm County Council; Swedish Research Council; Alzheimerfonden; Stiftelsen Sigurd och Elsa Goljes Minne; Stiftelsen Dementia; Swedish Research Council [2013-23897-104604-23, 2012-2291]; Swedish Heart Lung Foundation [20080409, 20100419]; Stockholm County Council [20090556, 20110120]

Available from: 2015-07-21 Created: 2015-07-20 Last updated: 2015-08-04

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Dahlström, Ulf
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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Cardiology in Linköping
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