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Sympathetic innervation of human muscle spindles
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy. Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.
2015 (English)In: Journal of Anatomy, ISSN 0021-8782, E-ISSN 1469-7580, Vol. 226, no 6, 542-548 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the present study was to investigate the presence of sympathetic innervation in human muscle spindles, using antibodies against neuropeptide Y (NPY), NPY receptors and tyrosine hydroxylase (TH). A total of 232 muscle spindles were immunohistochemically examined. NPY and NPY receptors were found on the intrafusal fibers, on the blood vessels supplying muscle spindles and on free nerve endings in the periaxial space. TH-immunoreactivity was present mainly in the spindle nerve and vessel. This is, to our knowledge, the first morphological study concerning the sympathetic innervation of the human muscle spindles. The results provide anatomical evidence for direct sympathetic innervation of the intrafusal fibers and show that sympathetic innervation is not restricted to the blood vessels supplying spindles. Knowledge about direct sympathetic innervation of the muscle spindle might expand our understanding of motor and proprioceptive dysfunction under stress conditions, for example, chronic muscle pain syndromes.

Place, publisher, year, edition, pages
2015. Vol. 226, no 6, 542-548 p.
Keyword [en]
chronic muscle pain, human skeletal muscles, muscle spindle, neuropeptide Y, neuropeptide Y receptors, sympathetic innervation, tyrosine hydroxylase
National Category
Physiology
Identifiers
URN: urn:nbn:se:umu:diva-106121DOI: 10.1111/joa.12309ISI: 000354884400005PubMedID: 25994126OAI: oai:DiVA.org:umu-106121DiVA: diva2:841793
Available from: 2015-07-14 Created: 2015-07-09 Last updated: 2017-12-04Bibliographically approved

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