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Plasma IL-5 concentration and subclinical carotid atherosclerosis
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2015 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 239, no 1, 125-130 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Genetic variants robustly associated with coronary artery disease were reported in the vicinity of the interleukin (IL)-5 locus, and animal studies suggested a protective role for IL-5 in atherosclerosis. Therefore, we set this work to explore IL-5 as a plasma biomarker for early subclinical atherosclerosis, as determined by measures of baseline severity and change over time of carotid intima-media thickness (cIMT).

Methods: We used biobank and databases of IMPROVE, a large European prospective cohort study of high-risk individuals (n = 3534) free of clinically overt cardiovascular disease at enrollment, in whom composite and segment-specific measures of cIMT were recorded at baseline and after 15 and 30 months. IL-5 was measured with an immunoassay in plasma samples taken at baseline.

Results: IL-5 levels were lower in women than in men, lower in the South than in North of Europe, and showed positive correlations with most established risk factors. IL-5 showed significant inverse relationships with cIMT change over time in the common carotid segment in women, but no significant relationships to baseline cIMT in either men or women.

Conclusions: Our results suggest that IL-5 may be part of protective mechanisms operating in early atherosclerosis, at least in women. However, the relationships are weak and whereas IL-5 has been proposed as a potential molecular target to treat allergies, it is difficult to envisage such a scenario in coronary artery disease.

Place, publisher, year, edition, pages
2015. Vol. 239, no 1, 125-130 p.
Keyword [en]
Interleukin-5, Atherosclerosis, Cytokines, Coronary artery disease, Intima-media thickness
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-101378DOI: 10.1016/j.atherosclerosis.2014.12.046ISI: 000349753800019PubMedID: 25587992OAI: oai:DiVA.org:umu-101378DiVA: diva2:840471
Available from: 2015-07-08 Created: 2015-03-30 Last updated: 2017-12-04Bibliographically approved

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