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The predictive value of arterial and valvular calcification for mortality and cardiovascular events
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology. Canterbury Christ Church University, Kent , UK.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology.
2014 (English)In: IJC Heart & Vessels, ISSN 2214-7632, Vol. 3, 1-5 p.Article, review/survey (Refereed) Published
Abstract [en]

A review of the predictive ability of arterial and valvular calcification has shown an additive effect of calcification in more than 1 location in predicting mortality and coronary heart disease, with mitral annual calcification being a particularly strong predictor. In individual arteries and valves there is a clear association between calcification presence, extent and progression and future cardiovascular events and mortality in asymptomatic, symptomatic and high risk patients, although adjustment for calcification in other arterial beds generally renders associations non-significant. Furthermore, in acute coronary syndrome, culprit plaque is normally not calcified. This would tend to reduce the validity of calcification as a predictor and suggest that the association with cardiovascular events and mortality may not be causal. The association with stroke is less clear; carotid and intracranial artery calcification show little predictive ability, with symptomatic plaques tending to be uncalcified.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 3, 1-5 p.
Keyword [en]
Calcification; Carotid/intracranial artery; Aortic valve
National Category
Cardiac and Cardiovascular Systems
URN: urn:nbn:se:umu:diva-105962DOI: 10.1016/j.ijchv.2014.02.001OAI: diva2:839357
Available from: 2015-07-02 Created: 2015-07-02 Last updated: 2015-07-21Bibliographically approved

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Nicoll, RachelHenein, Michael Y
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