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Comparing hepatic 2D and 3D magnetic resonance elastography methods in a clinical setting – Initial experiences
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics. Wolfram MathCore AB, Linköping, Sweden.ORCID iD: 0000-0003-4630-6550
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping.
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping.ORCID iD: 0000-0003-3124-8044
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.
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2015 (English)In: european journal o radiology open, Vol. 2, 66-70 p.Article in journal (Refereed) Published
Abstract [en]

Purpose

Continuous monitoring of liver fibrosis progression in patients is not feasible with the current diagnostic golden standard (needle biopsy). Recently, magnetic resonance elastography (MRE) has emerged as a promising method for such continuous monitoring. Since there are different MRE methods that could be used in a clinical setting there is a need to investigate whether measurements produced by these MRE methods are comparable. Hence, the purpose of this pilot study was to evaluate whether the measurements of the viscoelastic properties produced by 2D (stiffness) and 3D (elasticity and ‘Gabs,Elastic’) MRE are comparable.

Materials and methods

Seven patients with diffuse or suspect diffuse liver disease were examined in the same day with the two MRE methods. 2D MRE was performed using an acoustic passive transducer, with a 1.5 T GE 450 W MR system. 3D MRE was performed using an electromagnetic active transducer, with a 1.5 T Philips Achieva MR system. Finally, mean viscoelastic values were extracted from the same anatomical region for both methods by an experienced radiologist.

Results

Stiffness correlated well with the elasticity, R2 = 0.96 (P < 0.001; slope = 1.08, intercept = 0.61 kPa), as well as with ‘Gabs,ElasticR2 = 0.96 (P < 0.001; slope = 0.95, intercept = 0.28 kPa).

Conclusion

This pilot study shows that different MRE methods can produce comparable measurements of the viscoelastic properties of the liver. The existence of such comparable measurements is important, both from a clinical as well as a research perspective, since it allows for equipment-independent monitoring of disease progression.

Place, publisher, year, edition, pages
Elsevier, 2015. Vol. 2, 66-70 p.
Keyword [en]
Liver; Rheology; Elastography; Fibrosis; MRE; MRI
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-119848DOI: 10.1016/j.ejro.2015.04.001OAI: oai:DiVA.org:liu-119848DiVA: diva2:827391
Available from: 2015-06-26 Created: 2015-06-26 Last updated: 2017-01-23Bibliographically approved

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Forsgren, MikaelNorén, BengtKihlberg, JohanDahlqvist Leinhard, OlofKechagias, StergiosLundberg, Peter
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Center for Medical Image Science and Visualization (CMIV)Division of Radiological SciencesFaculty of Medicine and Health SciencesDepartment of Radiation PhysicsFaculty of Health SciencesDepartment of Radiology in LinköpingDivision of Cardiovascular MedicineDepartment of Gastroentorology
Radiology, Nuclear Medicine and Medical Imaging

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