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Ringer's lactate, but not hydroxyethyl starch, prolongs the food intolerance time after major abdominal surgery; an open-labelled clinical trial
Zhejiang University, Peoples R China; Shaoxing Peoples Hospital, Sweden.
Zhejiang University, Peoples R China.
Shaoxing Peoples Hospital, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Linköping.
2015 (English)In: BMC Anesthesiology, ISSN 1471-2253, Vol. 15Article in journal (Refereed) Published
Abstract [en]

Background: The infusion of large amounts of Ringers lactate prolongs the functional gastrointestinal recovery time and increases the number of complications after open abdominal surgery. We performed an open-labelled clinical trial to determine whether hydroxyethyl starch or Ringers lactate exerts these adverse effects when the surgery is performed by laparoscopy. Methods: Eighty-eight patients scheduled for major abdominal cancer surgery (83% by laparoscopy) received a first-line fluid treatment with 9 ml/kg of either 6% hydroxyethyl starch 130/0.4 (Voluven) or Ringers lactate, just after induction of anaesthesia; this was followed by a second-line infusion with 12 ml/kg of either starch or Ringers lactate over 1 hour. Further therapy was managed at the discretion of the attending anaesthetist. Outcome data consisted of postoperative gastrointestinal recovery time, complications and length of hospital stay. Results: The order of the infusions had no impact on the outcome. Both the administration of greater than= 2 L of Ringers lactate and the development of a surgical complication were associated with a longer time period of paralytic ileus and food intolerance (two-way ANOVA, P less than 0.02), but only surgical complications prolonged the length of hospital stay (P less than 0.001). The independent effect of Ringers lactate and complications of food intolerance time amounted to 2 days each. The infusion of greater than= 1 L of hydroxyethyl starch did not adversely affect gastrointestinal recovery. Conclusions: Ringers lactate, but not hydroxyethyl starch, prolonged the gastrointestinal recovery time in patients undergoing laparoscopic cancer surgery. Surgical complications prolonged the hospital stay.

Place, publisher, year, edition, pages
BioMed Central / Springer Verlag (Germany) , 2015. Vol. 15
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-119590DOI: 10.1186/s12871-015-0053-5ISI: 000355399400001PubMedID: 25943360OAI: diva2:825125

Funding Agencies|Qianjiang Talents Project of the Technology Office in Zhejiang province, PR of China [2012R10033]; Ostergotland City Council, Sweden [LiO-297751]

Available from: 2015-06-23 Created: 2015-06-22 Last updated: 2015-06-24

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Hahn, Robert
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Division of Drug ResearchFaculty of Medicine and Health SciencesDepartment of Anaesthesiology and Intensive Care in Linköping
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