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The Classical Pathways of Occipital Lobe Epileptic Propagation Revised in the Light of White Matter Dissection
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurosurgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Regenerative neurobiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurosurgery.
2015 (English)In: Behavioural Neurology, ISSN 0953-4180, E-ISSN 1875-8584, 872645Article in journal (Refereed) Published
Abstract [en]

The clinical evidences of variable epileptic propagation in occipital lobe epilepsy (OLE) have been demonstrated by several studies. However the exact localization of the epileptic focus sometimes represents a problem because of the rapid propagation to frontal, parietal, or temporal regions. Each white matter pathway close to the supposed initial focus can lead the propagation towards a specific direction, explaining the variable semiology of these rare epilepsy syndromes. Some new insights in occipital white matter anatomy are herein described by means of white matter dissection and compared to the classical epileptic patterns, mostly based on the central position of the primary visual cortex. The dissections showed a complex white matter architecture composed by vertical and longitudinal bundles, which are closely interconnected and segregated and are able to support specific high order functions with parallel bidirectional propagation of the electric signal. The same sublobar lesions may hyperactivate different white matter bundles reemphasizing the importance of the ictal semiology as a specific clinical demonstration of the subcortical networks recruited. Merging semiology, white matter anatomy, and electrophysiology may lead us to a better understanding of these complex syndromes and tailored therapeutic options based on individual white matter connectivity.

Place, publisher, year, edition, pages
2015. 872645
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-255314DOI: 10.1155/2015/872645ISI: 000354304900001OAI: oai:DiVA.org:uu-255314DiVA: diva2:822232
Available from: 2015-06-16 Created: 2015-06-15 Last updated: 2017-12-04Bibliographically approved

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Latini, FrancescoHjortberg, MatsAldskogius, HåkanRyttlefors, Mats
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