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Controlling Epileptiform Activity with Organic Electronic Ion Pumps
Aix Marseille University, France; INSERM, France.
Ecole National Super Mines, France.
Linköping University, Department of Science and Technology. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
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2015 (English)In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 27, no 20, 3138-3144 p.Article in journal (Refereed) Published
Abstract [en]

In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.

Place, publisher, year, edition, pages
Wiley-VCH Verlag , 2015. Vol. 27, no 20, 3138-3144 p.
Keyword [en]
Organic Bioelectronics, Organic Electronic Ion Pump, PEDOT:PSS, Neuroengineering
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URN: urn:nbn:se:liu:diva-119247DOI: 10.1002/adma.201500482ISI: 000354823600002PubMedID: 25866154OAI: diva2:821223

Funding Agencies|European Union [602102]; A*MIDEX [A_M-AAP-ID-13-24-130531-16.31-BERNARD-HLS]; Swedish Innovation Office (VINNOVA); Swedish Research Council [621-2011-3517]; Knut and Alice Wallenberg Foundation [2012.0302]; National Science Foundation [DMR-1105253]; ANR [ANR-13-BSV5-0019-01]; Fondation pour la Recherche Medicale [DBS20131128446]; Fondation de lAvenir; Onnesjo Foundation; Region PACA; Microvitae Technologies; Orthogonal, Inc.; Marie Curie Fellowships

Available from: 2015-06-15 Created: 2015-06-12 Last updated: 2015-07-02

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