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Ubiquinone-10 alters mechanical properties and increases stability of phospholipid membranes
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
2015 (English)In: Biochimica et Biophysica Acta - Biomembranes, ISSN 0005-2736, E-ISSN 1879-2642, Vol. 1848, no 10, 2233-2243 p.Article in journal (Refereed) Published
Abstract [en]

Abstract Ubiquinone-10 is mostly known for its role as an electron and proton carrier in aerobic cellular respiration and its function as a powerful antioxidant. Accumulating evidence suggest, however, that this well studied membrane component could have several other important functions in living cells. The current study reports on a previously undocumented ability of ubiquinone-10 to modulate the mechanical strength and permeability of lipid membranes. Investigations of DPH fluorescence anisotropy, spontaneous and surfactant induced leakage of carboxyfluorescein, and interactions with hydrophobic and hydrophilic surfaces were used to probe the effects caused by inclusion of ubiquinone-10 in the membrane of phospholipid liposomes. The results show that ubiquinone in concentrations as low as 2 mol.% increases the lipid packing order and condenses the membrane. The altered physicochemical properties result in a slower rate of release of hydrophilic components, and render the membrane more resistant towards rupture. As judged from comparative experiments using the polyisoprenoid alcohol solanesol, the quinone moiety is essential for the membrane stabilizing effects to occur. Our findings imply that the influence of ubiquinone-10 on the permeability and mechanical properties of phospholipid membranes is similar to that of cholesterol. The reported data indicate, however, that the molecular mechanisms are different in the two cases.

Place, publisher, year, edition, pages
2015. Vol. 1848, no 10, 2233-2243 p.
Keyword [en]
Coenzyme Q10, Liposomes, Leakage, Membrane stability, Solanesol
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-253627DOI: 10.1016/j.bbamem.2015.05.002ISI: 000362153400032OAI: oai:DiVA.org:uu-253627DiVA: diva2:815269
Funder
Swedish Research Council, 621-2011-3524Swedish Cancer Society, CAN20111504
Available from: 2015-05-29 Created: 2015-05-29 Last updated: 2017-12-04Bibliographically approved

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Publisher's full texthttp://www.sciencedirect.com/science/article/pii/S0005273615001509

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