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Glucose but not insulin or insulin resistance is associated with memory performance in middle-aged non-diabetic women: a cross sectional study
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
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2015 (English)In: Diabetology and Metabolic Syndrome, ISSN 1758-5996, Vol. 7, 20Article in journal (Refereed) Published
Abstract [en]

Background: Elevated concentrations of plasma glucose appear to play a role in memory impairment, and it has been suggested that insulin might also have a negative effect on cognitive function. Our aim was to study whether glucose, insulin or insulin resistance are associated with episodic or semantic memory in a non-diabetic and non-demented population. 

Methods: We linked and matched two population-based data sets identifying 291 participants (127 men and 164 women, mean age of 50.7 +/- 8.0 years). Episodic and semantic memory functions were tested, and fasting plasma insulin, fasting plasma glucose, and 2-hour glucose were analysed along with other potential influencing factors on memory function. Since men and women display different results on memory functions they were analysed separately. Insulin resistance was calculated using the HOMA-IR method. 

Results: A higher fasting plasma glucose concentration was associated with lower episodic memory in women (r = -0.08, 95% CI -0.14; -0.01), but not in men. Plasma insulin levels and insulin resistance were not associated with episodic or semantic memory in women or in men after adjustments for age, fasting glucose, 2-hour glucose, BMI, education, smoking, cardiovascular disease, hypertension, cholesterol, and physical activity. 

Conclusions: This indicates that fasting glucose but not insulin, might have impact on episodic memory in middle-aged women.

Place, publisher, year, edition, pages
2015. Vol. 7, 20
Keyword [en]
Cognition, Memory, Insulin, Insulin resistance, HOMA-IR, Glucose, Episodic memory, Semantic mory
National Category
Endocrinology and Diabetes
URN: urn:nbn:se:umu:diva-102450DOI: 10.1186/s13098-015-0014-7ISI: 000351195400001PubMedID: 25798199OAI: diva2:814865
Swedish Research Council, 345-2003-3883Swedish Research Council, 315-2004-6977
Available from: 2015-05-28 Created: 2015-04-26 Last updated: 2015-05-28Bibliographically approved

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