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Cyanobacterial Hydrogenases and Hydrogen Metabolism Revisited:: Recent Progress and Future Prospects
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics. (Microbial chemistry)
2015 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, Vol. 16, no 5, 10537-10561 p.Article, review/survey (Refereed) Published
Abstract [en]

Cyanobacteria have garnered interest as potential cell factories for hydrogen production. In conjunction with photosynthesis, these organisms can utilize inexpensive inorganic substrates and solar energy for simultaneous biosynthesis and hydrogen evolution. However, the hydrogen yield associated with these organisms remains far too low to compete with the existing chemical processes. Our limited understanding of the cellular hydrogen production pathway is a primary setback in the potential scale-up of this process. In this regard, the present review discusses the recent insight around ferredoxin/flavodoxin as the likely electron donor to the bidirectional Hox hydrogenase instead of the generally accepted NAD(P)H. This may have far reaching implications in powering solar driven hydrogen production. However, it is evident that a successful hydrogen-producing candidate would likely integrate enzymatic traits from different species. Engineering the [NiFe] hydrogenases for optimal catalytic efficiency or expression of a high turnover [FeFe] hydrogenase in these photo-autotrophs may facilitate the development of strains to reach target levels of biohydrogen production in cyanobacteria. The fundamental advancements achieved in these fields are also summarized in this review.

Place, publisher, year, edition, pages
2015. Vol. 16, no 5, 10537-10561 p.
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:uu:diva-253451DOI: 10.3390/ijms160510537ISI: 000356241400085PubMedID: 26006225OAI: diva2:814690
Knut and Alice Wallenberg Foundation
Available from: 2015-05-28 Created: 2015-05-28 Last updated: 2015-07-16Bibliographically approved

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