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Endostatin, Cathepsin S, and Cathepsin L, and Their Association with Inflammatory Markers and Mortality in Patients Undergoing Hemodialysis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
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2015 (English)In: Blood Purification, ISSN 0253-5068, E-ISSN 1421-9735, Vol. 39, no 4, 259-265 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND/AIMS: Although both endostatin and cathepsins S have been associated with higher mortality, data in patients with end-stage renal disease (ESRD) are scarce.

METHODS: A longitudinal cohort study of 207 prevalent patients undergoing hemodialysis.

RESULTS: Cathepsins S and L were associated with soluble receptors for tumor necrosis factor (sTNFR1 and sTNFR2, rho between 0.28 and 0.43, p < 0.001 for all). Weaker or absent associations between endostatin, cathepsins S and L were seen with other inflammatory biomarkers, that is, CRP, interleukin 6, pentraxin 3, and TNF. In Cox and Laplace regression models adjusted for age, sex, dialysis vintage, and diabetes: standard deviation increments of endostatin was associated with a lower mortality (hazard ratio 0.75, 95% confidence interval (CI) 0.57-0.98), and with 6.8 months longer median survival.

CONCLUSIONS: The high levels of endostatin, cathepsins S and L, and their associations with sTNFR1 and sTNFR2 warrant further studies exploring mortality, and the angiogenic and inflammatory pathways in ESRD.

Place, publisher, year, edition, pages
2015. Vol. 39, no 4, 259-265 p.
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Public Health, Global Health, Social Medicine and Epidemiology Hematology
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URN: urn:nbn:se:uu:diva-253176DOI: 10.1159/000381664ISI: 000357832300002PubMedID: 25924922OAI: oai:DiVA.org:uu-253176DiVA: diva2:813592
Available from: 2015-05-23 Created: 2015-05-23 Last updated: 2017-12-04Bibliographically approved

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