Change search
ReferencesLink to record
Permanent link

Direct link
Serum Levels of Oxylipins in Achilles Tendinopathy: An Exploratory Study
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology. Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Show others and affiliations
2015 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 10, no 4, e0123114Article in journal (Refereed) Published
Abstract [en]

Background: Linoleic acid-derived oxidation products are found in experimental pain models. However, little is known about the levels of such oxylipins in human pain. In consequence, in the present study, we have undertaken a lipidomic profiling of oxylipins in blood serum from patients with Achilles tendinopathy and controls.

Methodology/Principal findings: A total of 34 oxylipins were analysed in the serum samples. At a significance level of P<0.00147 (<0.05/34), two linoleic acid-derived oxylipins, 13-hydroxy-10E,12Z-octadecadienoic (13-HODE) and 12(13)-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME) were present at significantly higher levels in the Achilles tendinopathy samples. This difference remained significant when the dataset was controlled for age, gender and body-mass index. In contrast, 0/21 of the arachidonic acid- and 0/4 of the dihomo-γ-linolenic acid, eicosapentaenoic acid or docosahenaenoic acid-derived oxylipins were higher in the patient samples at this level of significance. The area under the Receiver-Operator Characteristic (ROC) curve for 12,13-DiHOME was 0.91 (P<0.0001). Levels of four N-acylethanolamines were also analysed and found not to be significantly different between the controls and the patients at the level of P<0.0125 (<0.05/4).

Conclusions/Significance: It is concluded from this exploratory study that abnormal levels of linoleic acid-derived oxylipins are seen in blood serum from patients with Achilles tendinopathy. Given the ability of two of these, 9- and 13-HODE to activate transient receptor potential vanilloid 1, it is possible that these changes may contribute to the symptoms seen in Achilles tendinopathy.

Place, publisher, year, edition, pages
2015. Vol. 10, no 4, e0123114
National Category
Rheumatology and Autoimmunity
URN: urn:nbn:se:umu:diva-103217DOI: 10.1371/journal.pone.0123114ISI: 000352845100135PubMedID: 25875933OAI: diva2:813064
Available from: 2015-05-21 Created: 2015-05-18 Last updated: 2015-05-21Bibliographically approved

Open Access in DiVA

fulltext(790 kB)59 downloads
File information
File name FULLTEXT01.pdfFile size 790 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Gouveia-Figueira, SandraNording, Malin L.Forsgren, StureFowler, Christopher J.
By organisation
PharmacologyDepartment of ChemistryDepartment of Integrative Medical Biology (IMB)
In the same journal
Rheumatology and Autoimmunity

Search outside of DiVA

GoogleGoogle Scholar
Total: 59 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 82 hits
ReferencesLink to record
Permanent link

Direct link