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Central arterial stiffness is increased among subjects with severe and very severe COPD: report from a population-based cohort study
Stockholm, Sweden.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology.ORCID iD: 0000-0002-2574-479X#sthash.m7dfPAkA.dpuf
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
Stockholm, Sweden.
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2015 (English)In: European Clinical Respiratory Journal, ISSN 2001-8525, Vol. 2, 27023Article in journal (Refereed) Published
Abstract [en]

Introduction: Cardiovascular disease (CVD) is common in chronic obstructive pulmonary disease (COPD) and is, as productive cough, related to poorer prognosis in COPD. Central arterial stiffness is a marker of early atherosclerosis, but the association between COPD, productive cough, and arterial stiffness as a possible indicator of CVD is unclear.

Objectives: To compare both arterial stiffness among subjects with and without COPD and the impact of productive cough in a population-based cohort.

Methods: A population-based cohort, including 993 COPD and 993 non-COPD subjects, has been invited to annual examination since 2005. In 2010, 947 subjects, of which 416 had COPD (according to the GOLD spirometric criteria), participated in examinations including structured interview, spirometry, and measurements of central arterial stiffness as pulse wave velocity (PWV).

Results: PWV was higher in GOLD 3–4 compared to non-COPD (10.52 vs. 9.13 m/s, p=0.042). CVD and age ≥60 were both associated with significantly higher PWV in COPD as well as in non-COPD. In COPD, those with productive cough had higher PWV than those without, significantly so in GOLD 1 (9.59 vs. 8.92 m/s, p=0.024). In a multivariate model, GOLD 3–4 but not productive cough was associated with higher PWV, when adjusted for sex, age group, smoking habits, blood pressure, CVD, and pulse rate.

Conclusions: GOLD 3–4, age ≥60, and CVD were associated with increased arterial stiffness, and also increased in COPD subjects with productive cough compared to those without. Of importance, GOLD 3–4 but not productive cough remained associated with increased central arterial stiffness when adjusted for confounders.

Place, publisher, year, edition, pages
co-action publishing , 2015. Vol. 2, 27023
National Category
Public Health, Global Health, Social Medicine and Epidemiology Respiratory Medicine and Allergy Cardiac and Cardiovascular Systems
URN: urn:nbn:se:umu:diva-103289DOI: 10.3402/ecrj.v2.27023OAI: diva2:812669
Available from: 2015-05-19 Created: 2015-05-19 Last updated: 2016-05-17Bibliographically approved

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