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Anergy in self-directed B lymphocytes: A statistical mechanics perspective
Dipartimento di Fisica, Universita` degli Studi di Parma, viale G. Usberti 7, 43100 Parma, Italy.
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.ORCID iD: 0000-0002-1252-2899
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2013 (English)In: Journal of Theoretical Biology, ISSN 0022-5193, E-ISSN 1095-8541, Vol. 375, 21-31 p.Article in journal (Refereed) Published
Abstract [en]

Self-directed lymphocytes may evade clonal deletion at ontogenesis but still remain harmless due to a mechanism called clonal anergy. For B-lymphocytes, two major explanations for anergy developed over the last decades: according to Varela theory, anergy stems from a proper orchestration of the whole B-repertoire, such that self-reactive clones, due to intensive feed-back from other clones, display strong inertia when mounting a response. Conversely, according to the model of cognate response, self-reacting cells are not stimulated by helper lymphocytes and the absence of such signaling yields anergy. Through statistical mechanics we show that helpers do not prompt activation of a sub-group of B-cells: remarkably, the latter are just those broadly interacting in the idiotypic network. Hence Varela theory can finally be reabsorbed into the prevailing framework of the cognate response model. Further, we show how the B-repertoire architecture may emerge, where highly connected clones are self-directed as a natural consequence of ontogenetic learning. 

Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 375, 21-31 p.
Keyword [en]
Immune networks, Lymphocyte homeostasis, Self-nonself-discrimination
National Category
Immunology
Identifiers
URN: urn:nbn:se:kth:diva-165820DOI: 10.1016/j.jtbi.2014.05.006ISI: 000354830700004Scopus ID: 2-s2.0-84988807155OAI: oai:DiVA.org:kth-165820DiVA: diva2:808851
Funder
EU, FP7, Seventh Framework Programme, 290038
Note

QC 20150430

Available from: 2015-04-29 Created: 2015-04-29 Last updated: 2017-12-04Bibliographically approved

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