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Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options
Emory University, GA 30322 USA; Yerkes National Primate Research Centre, GA 30329 USA.
Emory University, GA 30322 USA; Yerkes National Primate Research Centre, GA 30329 USA; University of Nebraska Medical Centre, NE USA.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
University of Malaya, Malaysia; University of Malaya, Malaysia; University of Malaya, Malaysia.
2015 (English)In: Retrovirology, ISSN 1742-4690, Vol. 12, no 14Article, review/survey (Refereed) Published
Abstract [en]

Virus-specific CD8(+) T cells play an important role in controlling viral infections including human immunodeficiency virus (HIV) infection. However, during chronic HIV infection, virus-specific CD8(+) T cells undergo functional exhaustion, lose effector functions and fail to control viral infection. HIV-specific CD8(+) T cells expressing high levels of co-inhibitory molecule programmed death-1 (PD-1) during the chronic infection and are characterized by lower proliferation, cytokine production, and cytotoxic abilities. Although, antiretroviral therapy has resulted in dramatic decline in HIV replication, there is no effective treatment currently available to eradicate viral reservoirs or restore virus-specific T or B-cell functions thatmay complement ART in order to eliminate the virus. In recent years, studies in mice and non-human primate models of HIV infection demonstrated the functional exhaustion of virus-specific T and B cells could be reversed by blockade of interaction between PD-1 and its cognate ligands (PD-L1 and PD-L2). In this review, we discuss recent advances in our understanding of PD-1 pathway in HIV/ SIV infection and discuss the beneficial effects of PD-1 blockade during chronic HIV/SIV infection and its potential role as immunotherapy for HIV/AIDS.

Place, publisher, year, edition, pages
BioMed Central , 2015. Vol. 12, no 14
Keyword [en]
HIV disease; PD-1 blockade; PD-1 pathway; SIV infection; T-cell dysfunction; B-cell dysfunction; PD-L1 and PD-L2
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-115820DOI: 10.1186/s12977-015-0144-xISI: 000350169400001PubMedID: 25756928OAI: diva2:796811

Funding Agencies|NIH [R01 A107183, R01 A1074417, RC2CA149086]; University of Malaya Research Grant (UMRG) of the Health and Translational Medicine Research Cluster, University of Malaya, Kuala Lumpur [RP021A-13HTM]

Available from: 2015-03-20 Created: 2015-03-20 Last updated: 2015-03-24

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