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Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.ORCID iD: 0000-0002-6060-6229
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
2014 (English)In: Typ1 ?Typ x Språk: - Engelska Svenska Norska Arabiska Bokmål Bulgariska Danska Engelska Esperanto Estniska Finska Franska Färöiska Grönländska (Kalaallit oqaasi) Hebreiska Hindi Indonesiska Iriska Isländska Italienska Japanska Katalanska Kinesiska Koreanska Kroatiska Kurdiska Latin Lettiska Litauiska Madurese Makedonska Mongoliskt språk Nederländska Norska Nygrekiska (1453-) Nynorsk Odefinierat språk Persiska Polska Portugisiska Rumänska Ryska Samiskt språk Sanskrit Serbiska Slovakiska Slovenska Spanska Svenska Tjeckiska Turkiska Tyska Ukrainska Ungerska Urdu Vietnamesiska / [ed] Prof Ulf Eriksson, 2014Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Aim

To test the hypothesis of a Betatrophin deficiency in patients with diabetes by measuring circulating Betatrophin in patients with type 2 diabetes (T2D) and non-diabetic, insulin resistant controls.

 

Material and methods

ELISA measured Betatrophin concentration in plasma of 27 patients with T2D and 18 matched controls. The participants were characterized by weight, height, waist-and hip (circumference and ratio), blood pressure, blood lipids, P-creatinine, fP-glucose, HbA1c, fC-peptide and family history of diabetes. Inputting fP-glucose and fC-peptide into the HOMA2 model assessed the beta-cell function, insulin sensitivity and insulin resistance.

 

Results

Betatrophin concentrations were approximately 40% higher in the patients with T2D and also correlated positively to HbA1c. In the control group, Betatrophin concentration increased with age. All T2D patients and controls were insulin resistant with mean insulin resistance in both groups well exceeding 2 and the insulin sensitivity being less than 50%.

 

Conclusion

In this first study to report on betatrophin concentrations in type 2 diabetes and insulin resistant patients, elevated betatrophin levels were measured in the diabetic individuals. There is no obvious betatrophin deficiency to substitute in these patients.

 

Place, publisher, year, edition, pages
2014.
Keyword [en]
Diabetes, Betatrophin
National Category
Family Medicine
Research subject
Family Medicine
Identifiers
URN: urn:nbn:se:uu:diva-246732OAI: oai:DiVA.org:uu-246732DiVA: diva2:794024
Conference
49th Annual Meeting of the Scandinavian Society for the Study of Diabetes (SSSD), 9-11 May, 2014, Uppsala, Sweden
Available from: 2015-03-10 Created: 2015-03-10 Last updated: 2015-03-13Bibliographically approved

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