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Role of ion channels in regulating Ca2+ homeostasis during the interplay between immune and cancer cells.
Leibniz Inst Neurobiol, D-39 Magdeburg, Germany.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences. Silesian Tech Univ, Inst Automat Control, Biosyst Grp, PL-44100 Gliwice, Poland.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences.
2015 (English)In: Cell Death and Disease, ISSN 2041-4889, E-ISSN 2041-4889, Vol. 19, no 6, e1648Article, review/survey (Refereed) Published
Abstract [en]

Ion channels are abundantly expressed in both excitable and non-excitable cells, thereby regulating the Ca2+ influx and downstream signaling pathways of physiological processes. The immune system is specialized in the process of cancer cell recognition and elimination, and is regulated by different ion channels. In comparison with the immune cells, ion channels behave differently in cancer cells by making the tumor cells more hyperpolarized and influence cancer cell proliferation and metastasis. Therefore, ion channels comprise an important therapeutic target in anti-cancer treatment. In this review, we discuss the implication of ion channels in regulation of Ca2+ homeostasis during the crosstalk between immune and cancer cell as well as their role in cancer progression.

Place, publisher, year, edition, pages
2015. Vol. 19, no 6, e1648
Keyword [en]
ion channels, cancer, Ca2+-influx, cytotoxic T cells, natural killer cells, anti-cancer immunity
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-115101DOI: 10.1038/cddis.2015.23ISI: 000350575800022PubMedID: 25695601OAI: oai:DiVA.org:liu-115101DiVA: diva2:793597
Available from: 2015-03-08 Created: 2015-03-08 Last updated: 2017-12-04Bibliographically approved

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