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Immunological persistence in 5 y olds previously vaccinated with hexavalent DTPa-HBV-IPV/Hib at 3, 5, and 11 months of age
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
2014 (English)In: Human Vaccines & Immunotherapeutics, ISSN 2164-5515, E-ISSN 2164-554X, Vol. 10, no 10, p. 2795-2798Article in journal (Refereed) Published
Abstract [en]

The combined diphtheria-tetanus-acellular pertussis-hepatitis B-poliomyelitis/Haemophilus influenza vaccine (DTPa-HBV-IPV/Hib: Infanrix hexa, GlaxoSmithKline Vaccines) is used for primary vaccination of infants in a range of schedules world-wide. Antibody persistence after 4 DTPa-HBV-IPV/Hib doses in the first 2 y of life has been documented, but long-term persistence data following the 3, 5, 11-12 months (3-5-11) infant vaccination schedule, employed for example in Nordic countries, are limited. We assessed antibody persistence in 57 5-year-old children who had received either DTPa-HBV-IPV/Hib or DTPa-IPV/Hib (Infanrix-IPV/Hib, GlaxoSmithKline Vaccines) in the 3-5-11 schedule. Among DTPa-HBV-IPV/Hib recipients, 7/12 retained seroprotective antibody concentrations for diphtheria, 10/12 for tetanus, 5/12 for hepatitis and 10/12 for Hib. Detectable antibodies were observed for 0/12 children for pertussis toxin (PT), 12/12 for filamentous haemagglutinin (FHA) and 8/12 for pertactin (PRN). Among DTPa-IPV/Hib recipients, 28/45 retained seroprotective anti-diphtheria concentrations, 34/44 for tetanus and 40/45 for Hib. Detectable antibodies were observed for 9/45 children for PT, 41/45 for FHA and 34/45 for PRN. Antibody persistence in DTPa-HBV-IPV/Hib and DTPa-IPV/Hib-vaccinees appeared similar in 5 y olds to that previously observed in children of a similar age who had received 4 prior doses of DTPa-HBV-IPV/Hib (or DTPa-IPV/Hib). As in subjects primed with 4 prior doses, we observed that antibodies markedly declined by 5 y of age, calling for the administration of a pre-school booster dose in order to ensure continued protection against pertussis.

Place, publisher, year, edition, pages
Landes Bioscience , 2014. Vol. 10, no 10, p. 2795-2798
Keywords [en]
antibody persistence, booster, vaccine, vaccination schedule, g, ml, micrograms per milliliter, CI, confidence interval, DTPa-HBV-IPV, Hib, - diphtheria-tetanus-acellular pertussis, hepatitis B, inactivated poliovirus and Haemophilus influenzae type b vaccine, DTPa-IPV, Hib, diphtheria-tetanus-acellular pertussis-inactivated poliovirus and Haemophilus influenzae type b vaccine, FHA, filamentous haemagglutinin, GMC, geometric mean antibody concentration, Hib, Haemophilus influenzae type b, HBs, anti-hepatitis B surface antigen, NA, not applicable, PRN, pertactin, PRP, polyribosylribitol phosphate, PT, pertussis toxin
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Immunology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-100304DOI: 10.4161/21645515.2014.970494ISI: 000348315500013PubMedID: 25483640OAI: oai:DiVA.org:umu-100304DiVA, id: diva2:792219
Available from: 2015-03-03 Created: 2015-02-27 Last updated: 2018-06-07Bibliographically approved

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