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Cancer Risk Assessment of Polycyclic Aromatic Hydrocarbon Contaminated Soils Determined Using Bioassay-Derived Levels of Benzo[a]pyrene Equivalents
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2015 (English)In: Environmental Science and Technology, ISSN 1086-931X, E-ISSN 1520-6912, Vol. 49, no 3, 1797-1805 p.Article in journal (Refereed) Published
Abstract [en]

Here we evaluate the excess lifetime cancer risk (ELCR) posed by 10 PAH-contaminated soils using (i) the currently advocated, targeted chemical-specific approach that assumes dose additivity for carcinogenic PAHs and (ii) a bioassay-based approach that employs the in vitro mutagenic activity of the soil fractions to determine levels of benzo[a]pyrene equivalents and, by extension, ELCR. Mutagenic activity results are presented in our companion paper.1 The results show that ELCR values for the PAH-containing fractions, determined using the chemical-specific approach, are generally (i.e., 8 out of 10) greater than those calculated using the bioassay-based approach; most are less than 5-fold greater. Only two chemical-specific ELCR estimates are less than their corresponding bioassay-derived values; differences are less than 10%. The bioassay-based approach, which permits estimation of ELCR without a priori knowledge of mixture composition, proved to be a useful tool to evaluate the chemical-specific approach. The results suggest that ELCR estimates for complex PAH mixtures determined using a targeted, chemical-specific approach are reasonable, albeit conservative. Calculated risk estimates still depend on contentious PEFs and cancer slope factors. Follow-up in vivo mutagenicity assessments will be required to validate the results and their relevance for human health risk assessment of PAH-contaminated soils

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2015. Vol. 49, no 3, 1797-1805 p.
National Category
Chemical Sciences
URN: urn:nbn:se:umu:diva-100344DOI: 10.1021/es504466bISI: 000349060300068OAI: diva2:791615
Available from: 2015-03-01 Created: 2015-03-01 Last updated: 2015-06-24Bibliographically approved

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Lundstedt, StaffanTysklind, Mats
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