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Neuroproteomics Tools in Clinical Practice
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry, Analytical Chemistry. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry. Uppsala University, Science for Life Laboratory, SciLifeLab.
2015 (English)In: Biochimica et Biophysica Acta - Proteins and Proteomics, ISSN 1570-9639, E-ISSN 1878-1454, Vol. 1854, no 7, 705-717 p.Article in journal (Refereed) Published
Abstract [en]

Abstract Neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) are characterized by neuronal impairment that leads to disease-specific changes in the neuronal proteins. The early diagnosis of these disorders is difficult, thus, the need for identifying, developing and using valid clinically applicable biomarkers that meet the criteria of precision, specificity and repeatability is very vital. The application of rapidly emerging technology such as mass spectrometry (MS) in proteomics has opened new avenues to accelerate biomarker discovery, both for diagnostic as well as for prognostic purposes. This review summarizes the most recent advances in the mass spectrometry-based neuroproteomics and analyses the current and future directions in the biomarker discovery for the neurodegenerative diseases.11 This article is part of a Special Issue entitled: Neuroproteomics: Applications in Neuroscience and Neurology.

Place, publisher, year, edition, pages
2015. Vol. 1854, no 7, 705-717 p.
Keyword [en]
Proteomics, Quantitative neuroproteomics, Neurodegenerative disease, Mass spectrometry
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-244132DOI: 10.1016/j.bbapap.2015.01.016ISI: 000355036500002OAI: oai:DiVA.org:uu-244132DiVA: diva2:787887
Available from: 2015-02-12 Created: 2015-02-12 Last updated: 2017-12-04Bibliographically approved

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Publisher's full texthttp://www.sciencedirect.com/science/article/pii/S1570963915000370

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Shevchenko, GannaKonzer, AnneMusunuri, SravaniBergquist, Jonas
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