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Decreased binding capacity (Bmax) of muscarinic acetylcholine receptors in fibroblasts from boys with attention-deficit/hyperactivity disorder (ADHD)
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. (Experimentell neuropsykiatri)
Unit of Neurodevelopmental Disorders, Department of Paediatrics, Skaraborg Hospital, Mariestad.
Unit of Neurodevelopmental Disorders, Department of Paediatrics, Skaraborg Hospital, Mariestad; The Research and Development Centre, Skaraborg Hospital, Skövde; The Gillberg Neuoropsychiatry Centre, Sahlgrenska Academy, Gothenburg.
Department of Neuroscience, Psychiatry, Uppsala University Hospital, Gothenburg.
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2013 (English)In: ADHD Attention Deficit and Hyperactivity Disorders, ISSN 1866-6116, E-ISSN 1866-6647, Vol. 5, no 3, 267-271 p.Article in journal (Refereed) Published
Abstract [en]

Monoaminergic dysregulation is implicated in attention-deficit/hyperactivity disorder (ADHD), and methylphenidate and amphetamines are the most frequently prescribed pharmacological agents for treating ADHD. However, it has recently been proposed that the core symptoms of the disorder might be due to an imbalance between monoaminergic and cholinergic systems. In this study, we used fibroblast cell homogenates from boys with and without ADHD as an extraneural cell model to examine the cholinergic receptor density, that is, muscarinic acetylcholine receptors (mAChRs). We found that the binding capacity (Bmax) of [³H] Quinuclidinyl benzilate (³H-QNB) to mAChRs was decreased by almost 50 % in the children with ADHD (mean = 30.6 fmol/mg protein, SD = 25.6) in comparison with controls [mean = 63.1 fmol/mg protein, SD = 20.5, p ≤ 0.01 (Student's unpaired t test)]. The decreased Bmax indicates a reduced cholinergic receptor density, which might constitute a biomarker for ADHD. However, these preliminary findings need to be replicated in larger ADHD and comparison cohorts

Place, publisher, year, edition, pages
Berlin, Germany: Springer Berlin/Heidelberg, 2013. Vol. 5, no 3, 267-271 p.
Keyword [en]
ADHD, Fibroblaster, Muscarinic acetylcholine receptor, Receptor binding assay, Biomarker
National Category
Medical and Health Sciences Psychiatry
Research subject
Psychiatry; Biomedicine
URN: urn:nbn:se:oru:diva-42579DOI: 10.1007/s12402-013-0103-0PubMedID: 23389940ScopusID: 2-s2.0-84883061295OAI: diva2:787725
Östergötland County Council, FoUcenter Dr 91021Swedish Research Council, K2007-62X-08318-20-3The Karolinska Institutet's Research Foundation
Available from: 2015-02-11 Created: 2015-02-11 Last updated: 2015-09-07Bibliographically approved

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Johansson, JessicaVenizelos, Nikolaos
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School of Health and Medical Sciences, Örebro University, Sweden
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Medical and Health SciencesPsychiatry

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