Ultrasound speckle tracking strain estimation of in vivo carotid artery plaque with in vitro sonomicrometry validation
2015 (English)In: Ultrasound in Medicine and Biology, ISSN 0301-5629, E-ISSN 1879-291X, Vol. 41, no 1, 77-88 p.Article in journal (Refereed) Published
Our objective was to validate a previously developed speckle tracking (ST) algorithm to assess strain in common carotid artery plaques. Radial and longitudinal strain was measured in common carotid artery gel phantoms with a plaque-mimicking inclusion using an in-house ST algorithm and sonomicrometry. Moreover, plaque strain by ST for seven patients (77 ± 6 y) with carotid atherosclerosis was compared with a quantitative visual assessment by two experienced physicians. In vitro, good correlation existed between ST and sonomicrometry peak strains, both radially (r = 0.96, p < 0.001) and longitudinally (r = 0.75, p < 0.01). In vivo, greater pulse pressure-adjusted radial and longitudinal strains were found in echolucent plaques than in echogenic plaques. This illustrates the feasibility of ultrasound ST strain estimation in plaques and the possibility of characterizing plaques using ST strain in vivo.
Place, publisher, year, edition, pages
Elsevier, 2015. Vol. 41, no 1, 77-88 p.
Carotid artery, Invitro, Invivo, Phantom, Plaque characterization, Speckle tracking, Strain, Ultrasound, Validation
Medical Image Processing
IdentifiersURN: urn:nbn:se:kth:diva-159741DOI: 10.1016/j.ultrasmedbio.2014.06.013ISI: 000347898500011PubMedID: 25308946ScopusID: 2-s2.0-84919843935OAI: oai:DiVA.org:kth-159741DiVA: diva2:787184
QC 20150220. QC 201602262015-02-092015-02-092016-09-21Bibliographically approved