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Curative electrochemotherapy in the head and neck area
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro university , 2015. , 94 p.
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 117
National Category
Surgery
Research subject
Surgery
Identifiers
URN: urn:nbn:se:oru:diva-42215ISBN: 978-91-7529-061-4 (print)OAI: oai:DiVA.org:oru-42215DiVA: diva2:783323
Public defence
2015-03-06, Universitetssjukhuset, Bomanssonsalen, Södra Grev Rosengatan, Örebro, 13:00 (English)
Opponent
Supervisors
Available from: 2015-01-26 Created: 2015-01-26 Last updated: 2017-10-17Bibliographically approved
List of papers
1. Electroporation therapy of skin cancer in the head and neck area.
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2010 (English)In: Dermatologic Surgery, ISSN 1076-0512, E-ISSN 1524-4725, Vol. 36, no 8, 1245-50 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Electroporation therapy is a new cancer treatment modality in which a locally applied electrical field enhances cell membrane permeability, allowing greater intracellular accumulation of a chemotherapeutic agent.

OBJECTIVE: To evaluate the efficacy of electroporation therapy in treating basal cell and squamous cell carcinomas of the skin.

MATERIALS AND METHODS: Six patients with skin cancer of the head and neck were treated using electroporation therapy with intratumorally injected bleomycin. Orbital growth, facial nerve proximity, or proximity to cartilage of the external meatus complicated four of these tumors. The intention was curative. The follow-up period was 24 months and included biopsies after 8 weeks.

RESULTS: In four of the six patients, one treatment was enough to eradicate the tumor. In one patient, the tumor persisted even after a second treatment with electroporation therapy. A septal cartilage perforation was the only major complication. The cosmetic results were very satisfactory. One additional recurrence was recorded 6 months after the follow-up period

CONCLUSION: Electroporation therapy is a promising new cancer treatment that should be further evaluated as an alternative to surgery, especially in complicated skin cancer.

Keyword
Electroporation therapy, tumor control, basal cell carcinoma, squamous cell carcinoma, BCC, SCC
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
urn:nbn:se:oru:diva-37223 (URN)10.1111/j.1524-4725.2010.01617.x (DOI)000280457400005 ()20666812 (PubMedID)2-s2.0-77955152383 (Scopus ID)
Note

Funding agencies:

Orebro County Council  

Inovio Biomedical Corporation  

Genetronics, Inc. 

Genetronics, Inc. provided financial support for this study and has paid Dr. L. Lofgren an honorarium forwork at investigator meetings.

Available from: 2014-09-29 Created: 2014-09-29 Last updated: 2017-12-05Bibliographically approved
2. Electroporation therapy for T1 and T2 oral tongue cancer
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2011 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 131, no 6, 660-664 p.Article in journal (Refereed) Published
Abstract [en]

Conclusion: Electroporation therapy appears to be a safe treatment achieving excellent local tumor control and very good functional results in our study and it should be further clinically evaluated.

Objectives: The objectives of this study were to assess local tumor control, survival, and effects on speech and eating after treatment of tongue cancer with electroporation therapy, a new local therapeutic modality. In this approach intracellular accumulation of a chemotherapeutic agent is achieved by using a locally applied electrical field.

Methods: Fifteen patients with primary T1 and T2 oral tongue cancer were treated with electroporation therapy with intratumorally administered bleomycin. Postoperative radiotherapy was performed when the tumor infiltration was 5 mm or more. The follow-up time was 24 months for the surviving patients and 20.4 months overall. The effects on eating and speech were assessed using the PSS-HN scale and voice recordings.

Results: No local recurrence was recorded in any patient during the follow-up. Three patients died, two from progressive regional disease. Of the 12 surviving patients, 2 patients had regional recurrence and 10 patients including the 5 patients treated with EPT alone were tumor-free both locally and regionally at the last follow-up. The functional outcome for speech and eating were very good.

Place, publisher, year, edition, pages
Informa Healthcare, 2011
Keyword
Electrochemotherapy, bleomycin, local control, survival, speech
National Category
Otorhinolaryngology
Identifiers
urn:nbn:se:oru:diva-42889 (URN)10.3109/00016489.2010.541937 (DOI)000290571200015 ()21190422 (PubMedID)2-s2.0-79956051975 (Scopus ID)
Note

Funding agency: Örebro County Council; Genetronics Inc.

Available from: 2015-02-23 Created: 2015-02-23 Last updated: 2017-12-04Bibliographically approved
3. Electrochemotherapy - possible benefits and limitations to its use in the head and neck region
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2015 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 135, no 1, 90-95 p.Article in journal (Refereed) Published
Abstract [en]

Conclusion: Electrochemotherapy (ECT) is an efficacious treatment. It should, however, be used with some caution in the treatment of head and neck cancer.

Objectives: To assess local tumor control, safety, survival, and functional outcome after treatment of cancer in the head and neck region with ECT.

Methods: Four patients with primary T2 cancer of the oral cavity or oropharynx and one patient with a metastasis of renal cancer in the masseter muscle were treated with ECT with intratumorally administered bleomycin. Control biopsies were carried out 2 months after treatment. Postoperative radiotherapy was performed based on tumor T-stage and the depth of tumor infiltration. Serious adverse events and treatment malfunctions were recorded. The follow-up time was 24 months for the surviving patients and 20 months overall. The PSS-HN scale was used to assess the functional outcome.

Results: No local recurrence was recorded in any patient during the follow-up. However, only one patient was treated with ECT alone. There were four serious adverse events: one nearly lethal bleeding, two cases of osteoradionecrosis, and a fistula. One patient died from distant metastasis. The other patients were tumor-free both locally and overall at 24 months. The median functional outcome in all parameters was worse 1 year after treatment.

Place, publisher, year, edition, pages
Informa Healthcare, 2015
National Category
Otorhinolaryngology
Identifiers
urn:nbn:se:oru:diva-39848 (URN)10.3109/00016489.2014.947655 (DOI)000346275600013 ()25496181 (PubMedID)2-s2.0-84918592776 (Scopus ID)
Note

Funding agency: Genetronics Inc., San Diego, CA, USA

Available from: 2014-12-16 Created: 2014-12-16 Last updated: 2017-12-05Bibliographically approved
4. Long-term follow-up in patients treated with curative electrochemotherapy
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(English)Manuscript (preprint) (Other academic)
National Category
Otorhinolaryngology
Identifiers
urn:nbn:se:oru:diva-42890 (URN)
Available from: 2015-02-23 Created: 2015-02-23 Last updated: 2017-10-17Bibliographically approved
5. Electrochemotherapy - evidence for cell-type selectivity in vitro
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(English)Manuscript (preprint) (Other academic)
National Category
Otorhinolaryngology
Identifiers
urn:nbn:se:oru:diva-42891 (URN)
Available from: 2015-02-23 Created: 2015-02-23 Last updated: 2017-10-17Bibliographically approved

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