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Expected number of breakpoints after t random reversals in genomes with duplicate genes
Mathematical Sciences, Göteborg University and Chalmers University of Technology, Göteborg.ORCID iD: 0000-0002-6444-7878
2008 (English)In: Discrete Applied Mathematics, ISSN 0166-218X, E-ISSN 1872-6771, Vol. 156, no 12, 2320-2335 p.Article in journal (Refereed) Published
Abstract [en]

In comparative genomics, one wishes to deduce the evolutionary distance between different species by studying their genomes. Using gene order information, we seek the number of times the gene order has changed between two species. One approach is to compute the method of moments estimate of this edit distance from a measure of dissimilarity called the breakpoint measure. In this paper, we extend formulae and bounds of this estimate on gene permutations to genomes with duplicate genes.

Place, publisher, year, edition, pages
Amsterdam, Netherlands: Elsevier, 2008. Vol. 156, no 12, 2320-2335 p.
Keyword [en]
Genomic distance, Reversal, Breakpoint, Expected distance, Method of moments estimate
National Category
Mathematics
Research subject
Mathematics; Mathematics
Identifiers
URN: urn:nbn:se:oru:diva-41702DOI: 10.1016/j.dam.2007.10.023ISI: 000259431300009Scopus ID: 2-s2.0-49149130679OAI: oai:DiVA.org:oru-41702DiVA: diva2:780953
Available from: 2015-01-15 Created: 2015-01-15 Last updated: 2017-12-05Bibliographically approved

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