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Expected Gene Order Distances and Model Selection in Bacteria
Department of Computing Science and Engineering, Chalmers University of Technology, Gothenburg.
Department of Mathematical Sciences, Gothenburg University and Chalmers University of Technology, Gotenhburg.ORCID iD: 0000-0002-6444-7878
2008 (English)In: Bioinformatics, ISSN 1367-4803, E-ISSN 1367-4811, Vol. 24, no 11, 1332-1338 p.Article in journal (Refereed) Published
Abstract [en]

Motivation: The evolutionary distance inferred from gene order comparisons of related bacteria is dependent on the model. Therefore, it is highly important to establish reliable assumptions before inferring its magnitude.

Results: We investigate the patterns of dotplots between species of bacteria with the purpose of model selection in gene order problems. We find several categories of data which can be explained by carefully weighing the contributions of reversals, transpositions, symmetrical reversals, single gene transpositions, and single gene reversals. We also derive method of moments distance estimates for some previously uncomputed cases, such as symmetrical reversals, single gene reversals and their combinations, as well as the single gene transpositions edit distance.

Place, publisher, year, edition, pages
Oxford, United Kingdom: Oxford University Press, 2008. Vol. 24, no 11, 1332-1338 p.
National Category
Bioinformatics and Systems Biology
URN: urn:nbn:se:oru:diva-41693DOI: 10.1093/bioinformatics/btn111ISI: 000256169300002PubMedID: 18381402ScopusID: 2-s2.0-84871214699OAI: diva2:780944
Available from: 2015-01-15 Created: 2015-01-15 Last updated: 2015-10-01Bibliographically approved

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