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Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect
Abo Akad University, Finland.
Abo Akad University, Finland.
Abo Akad University, Finland.
Linköping University, Department of Physics, Chemistry and Biology, Nanostructured Materials. Linköping University, The Institute of Technology.
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2015 (English)In: BIOMATERIALS SCIENCE, ISSN 2047-4830, Vol. 3, no 1, 103-111 p.Article in journal (Refereed) Published
Abstract [en]

Targeted cancer therapies are currently a strong focus in biomedical research. The most common approach is to use nanocarrier-based targeting to specifically deliver conventional anticancer drugs to enhance their therapeutic efficacy, increase bioavailability, and decrease the side-effects on normal cells. A step further towards higher specificity and efficacy would be to employ specific novel drugs along with specific nanocarrier-based targeting. Our recent studies have demonstrated that a plant-derived diterpenoid compound, anisomelic acid (AA), induces apoptosis in cervical cancer cells. In this work, we describe the development of a folic acid (FA)-targeted AA delivery system using chitosan-coated rod-shaped mesoporous silica particles (Chitosan-NR-MSP). The cellular internalization and uptake enhancement of the FA-Chitosan-NR-MSP towards cancerous folate receptor (FR)-positive (SiHa and HeLa) and/or normal FR-negative (HEK 293) cells were assessed, which indicated that the intracellular uptake of FA-conjugated Chitosan-NR-MSP was more target-specific. Furthermore, the induction of apoptosis by AA-loaded chitosan-coated rod-shaped particles on SiHa cells was studied. By employing caspase-3 activation and PARP cleavage as measure of apoptosis, the FA-particle mediated AA treatment was clearly more effective, significantly enhancing apoptosis in comparison to non-targeted Chitosan-NR-MSP or free AA in SiHa cells, suggesting that the FA-Chitosan-NR-MSPs can be potentially utilized as a drug delivery system for cervical cancer treatment.

Place, publisher, year, edition, pages
Royal Society of Chemistry , 2015. Vol. 3, no 1, 103-111 p.
National Category
Physical Sciences
URN: urn:nbn:se:liu:diva-113162DOI: 10.1039/c4bm00278dISI: 000345908400011OAI: diva2:780361

Funding Agencies|Sigrid Juselius Foundation; Center of Excellence for Functional Materials; Nanolith Sverige AB; Academy of Finland [140193, 260599, 278812]

Available from: 2015-01-14 Created: 2015-01-12 Last updated: 2015-01-29

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