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Subjective cognitive impairment subjects in our clinical practice
Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Sweden.
Department of Clinical Science, Intervention and Technology, Care Sciences and Society, Karolinska Institutet, Sweden.
Jönköping University, School of Health Science, HHJ, Institute of Gerontology.
Karolinska Institutet Alzheimer Disease Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Sweden.
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2014 (English)In: Dementia and geriatric cognitive disorders extra, E-ISSN 1664-5464, Vol. 4, no 3, 419-430 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

The clinical challenge in subjective cognitive impairment (SCI) is to identify which individuals will present cognitive decline. We created a statistical model to determine which variables contribute to SCI and mild cognitive impairment (MCI) versus Alzheimer's disease (AD) diagnoses.

METHODS:

A total of 993 subjects diagnosed at a memory clinic (2007-2009) were included retrospectively: 433 with SCI, 373 with MCI and 187 with AD. Descriptive statistics were provided. A logistic regression model analyzed the likelihood of SCI and MCI patients being diagnosed with AD, using age, gender, Mini-Mental State Examination score, the ratio of β-amyloid 42 divided by total tau, and phosphorylated tau as independent variables.

RESULTS:

The SCI subjects were younger (57.8 ± 8 years) than the MCI (64.2 ± 10.6 years) and AD subjects (70.1 ± 9.7 years). They were more educated, had less medial temporal lobe atrophy (MTA) and frequently normal cerebrospinal fluid biomarkers. Apolipoprotein E4/E4 homozygotes and apolipoprotein E3/E4 heterozygotes were significantly less frequent in the SCI group (6 and 36%) than in the AD group (28 and 51%). Within the regression model, cardiovascular risk factors, confluent white matter lesions, MTA and central atrophy increased the AD likelihood for SCI subjects.

CONCLUSIONS:

SCI patients form a distinct group. In our model, factors suggesting cardiovascular risk, MTA and central atrophy increased the AD likelihood for SCI subjects.

Place, publisher, year, edition, pages
2014. Vol. 4, no 3, 419-430 p.
Keyword [en]
Alzheimer's disease; Dementia; Mild cognitive impairment
National Category
Gerontology, specializing in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hj:diva-25614DOI: 10.1159/000366270PubMedID: 25538726Local ID: HHJÖvrigtISOAI: oai:DiVA.org:hj-25614DiVA: diva2:779847
Available from: 2015-01-13 Created: 2015-01-13 Last updated: 2017-12-05Bibliographically approved

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