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TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells
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2015 (English)In: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 10, no 1, 20-28 p.Article in journal (Refereed) Published
Abstract [en]

TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. We find that NPCs use TRIM28-mediated histone modifications to dynamically regulate transcription and silencing of ERVs, which is in contrast to other somatic cell types using DNA methylation. We also show that derepression of ERVs influences transcriptional dynamics in NPCs through the activation of nearby genes and the expression of long noncoding RNAs. These findings demonstrate a unique dynamic transcriptional regulation of ERVs in NPCs. Our results warrant future studies on the role of ERVs in the healthy and diseased brain.

Place, publisher, year, edition, pages
Elsevier, 2015. Vol. 10, no 1, 20-28 p.
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:uu:diva-240748DOI: 10.1016/j.celrep.2014.12.004ISI: 000347465600003ISBN: 2211-1247 (Electronic) (print)OAI: oai:DiVA.org:uu-240748DiVA: diva2:777047
Available from: 2015-01-08 Created: 2015-01-08 Last updated: 2017-12-05Bibliographically approved

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Publisher's full texthttp://www.ncbi.nlm.nih.gov/pubmed/25543143

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Science for Life Laboratory, SciLifeLabDepartment of Medical Biochemistry and Microbiology
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