Temperature-controlled in vivo ocular exposure to 1090-nm radiation suggests that near-infrared radiation cataract is thermally induced
2015 (English)In: Journal of Biomedical Optics, ISSN 1083-3668, E-ISSN 1560-2281, Vol. 20, no 1, 015003Article in journal (Refereed) Published
The damage mechanism for near infrared radiation induced (IRR) cataract is unclear. Both a photochemical and a thermal mechanism were suggested.
The current paper aims to elucidate a photochemical effect based on investigation of irradiance-exposure time reciprocity.
Groups of 20 rats were unilaterally exposed to 96 W/cm2 IRR at 1090 nm within the dilated pupil accumulating 57, 103, 198, 344 kJ/cm2 respectively. Temperature was recorded at the limbus of the exposed eye. Seven days after exposure, the lenses were macroscopically imaged and light scattering was measured quantitatively.
The average maximum temperature increase for exposure time 10, 18, 33, 60 minutes was expressed as CI(0.95); 7.0±1.1, 6.8±1.1, 7.6±1.3, 7.4±1.1 ºC at the limbus of the exposed eye. The difference of light scattering in the lenses between exposed and contralateral not exposed eyes was 0.00±0.02, 0.01±0.03, -0.01±0.02, -0.01±0.03 tEDC, respectively and no apparent morphological changes in the lens were observed.
An exposure to 96 W/cm2 1090 nm IRR projected on the cornea within the dilated pupil accumulating radiant exposures up to 344 kJ/cm2 does not induce cataract if the temperature rise at the limbus is below 8 °C. This is consistent with a thermal damage mechanism for IRR induced cataract.
Place, publisher, year, edition, pages
2015. Vol. 20, no 1, 015003
infrared radiation, temperature, forward light scattering, lens
IdentifiersURN: urn:nbn:se:uu:diva-240718DOI: 10.1117/1.JBO.20.1.015003ISI: 000350206400007PubMedID: 25602780OAI: oai:DiVA.org:uu-240718DiVA: diva2:776986