MRI estimated placental perfusion in fetal growth assessment
2015 (English)In: Ultrasound in Obstetrics and Gynecology, ISSN 0960-7692, E-ISSN 1469-0705, Vol. 46, no 6, 700-705 p.Article in journal (Refereed) Published
This study aimed to evaluate placental perfusion fraction estimated by magnetic resonance imaging (MRI) in vivo as a marker of placental function.
The study population included 35 pregnant women, of whom 13 had preeclampsia, examined at gestational weeks 22 to 40. Each woman underwent, within a 24 hour period: a MRI diffusion-weighted sequence (from which we calculated the placental perfusion fraction); venous blood sampling; and an ultrasound examination including estimation of fetal weight, amniotic fluid index and Doppler velocity measurements. We compared the perfusion fraction in pregnancies with and without fetal growth restriction and estimated correlations between the perfusion fraction and ultrasound estimates and plasma markers with linear regression. The associations between the placental perfusion fraction and ultrasound estimates were modified by the presence of preeclampsia (p < 0.05) and therefore we included an interaction term between preeclampsia and the covariates in the models.
The median placental perfusion fraction in pregnancies with and without fetal growth restriction was 21% and 32%, respectively (p = 0.005). The correlations between the placental perfusion fraction and ultrasound estimates and plasma markers were highly significant (p-values 0.002 to 0.0001). The highest coefficient of determination (R2= 0.56) for placental perfusion fraction was found for a model including pulsatility index in ductus venosus, plasma level of sFlt1, estimated fetal weight and presence of preeclampsia.
The placental perfusion fraction has potential to contribute to the clinical assessment in cases of placental insufficiency.
Place, publisher, year, edition, pages
2015. Vol. 46, no 6, 700-705 p.
Intrauterine growth restriction, Small for gestational age, Magnetic resonance imaging, Placenta, Perfusion, Perfusion fraction
Obstetrics, Gynecology and Reproductive Medicine Radiology, Nuclear Medicine and Medical Imaging
Research subject Medical Science
IdentifiersURN: urn:nbn:se:uu:diva-239293DOI: 10.1002/uog.14786ISI: 000365855700011PubMedID: 25640054OAI: oai:DiVA.org:uu-239293DiVA: diva2:774028
FunderSwedish Research Council, 2014-3561