Self-reported sleep disturbance is associated with Alzheimer's disease risk in men
2015 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 11, no 9, 1090-1097 p.Article in journal (Refereed) Published
OBJECTIVE: To study the association between self-reported sleep disturbances and dementia risk.
METHODS: Self-reported sleep disturbances and established risk factors for dementia were measured in men at ages 50 (n = 1574) and 70 (n = 1029) years. Dementia incidence was determined by reviewing their patient history between ages 50 and 90 years. In addition, plasma levels of β-amyloid (Aβ) peptides 1-40 and 1-42 were measured at ages 70, 77, and 82 years.
RESULTS: Cox regression demonstrated that men with self-reported sleep disturbances had a higher risk of developing dementia (+33%) and Alzheimer's disease (AD, +51%) than men without self-reported sleep disturbances (both P < .05). Binary logistic regression showed the increased risk for both dementia (+114%) and AD (+192%) were highest when sleep disturbance was reported at age 70 years (both P < .001). No group differences were found in Aβ levels.
CONCLUSION: Improving sleep quality may help reduce the neurodegenerative risk in older men.
Place, publisher, year, edition, pages
2015. Vol. 11, no 9, 1090-1097 p.
IdentifiersURN: urn:nbn:se:uu:diva-238748DOI: 10.1016/j.jalz.2014.08.104ISI: 000361569000009PubMedID: 25438949OAI: oai:DiVA.org:uu-238748DiVA: diva2:772057
FunderSwedish Research CouncilÅke Wiberg FoundationNovo Nordisk