Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A Randomized Open Comparative Clinical Trial on the Effectiveness, Safety and Tolerability of a Homeopathic Medicinal Product for the Treatment of Painful Teething in Children
Mid Sweden University, Faculty of Human Sciences, Department of Nursing Sciences. (Omvårdnad)
Department Nutrition & Health, Louis Bolk Institute, Driebergen, The Netherlands.
Louis Bolk Institute, The Netherlands.
Deutsche Homöopathie-Union, DHU-Arzneimittel GmbH & Co. KG, Karlsruhe, Germany.
Show others and affiliations
2015 (English)In: Journal of Alternative & Integrative Medicine, ISSN 2327-5162, Vol. 4, no 1, 1000178Article in journal (Refereed) Published
Abstract [en]

Background: Homeopathic products are sold over the counter and are often used for treatment of self-limiting complaints in children such as painful teething. Objective: To investigate the effectiveness, safety and tolerability of the homeopathic product ChamBell-5-02, in the treatment of children with painful teething in comparison to another homeopathic product. Design: A multicenter, randomized, open, comparative clinical trial with two parallel treatment groups at three outpatient pediatric clinics in Russia. Methods: Children aged ≤ six years with painful teething were enrolled from March-July 2009 in the study and randomized to receive either ChamBell-5-02 tablets (Dentokind®; intervention group) or homeopathic suppositories (Viburcol®; control group). Exclusion criteria were: fever of ≥38°C and severe comorbidity. Primary effectiveness endpoints were change of total severity scores of subjective complaints (TSSC) and clinical signs (TSCS) rated by investigators after seven days of treatment. Treatment satisfaction and safety (via number of adverse events (AEs)) were assessed. Results: A total of 200 children (100 per group) were included and analyzed. TSSC/ TSCS decreased after the 7- day treatment period from median 7.0 to 1.0/6.0 to 1.0 points in the intervention group and from median 5.0 to 1.0/5.5 to 1.0 points in the control group. Compared to the control group children receiving ChamBell-5-02 had about five/2.5 time higher odds of showing improvement (TSSC/TSCS: odds ratio resulting from proportional odds model was 5.1 (95%-CI: 2.7-9.4, p<0.0001) / 2.5 (95%-CI: 1.5-4.4, p=0.0011). Furthermore the intervention group showed a more favorable outcome regarding treatment satisfaction (ratings very satisfied: intervention group: n=94; control group: n=58). No AEs were recorded in the intervention group. In the control group three mild to moderate, nonserious AEs occurred. Conclusions: Overall it can be concluded that in this study ChamBell-5-02 tablets showed to be effective, safe and well tolerated.

 

Place, publisher, year, edition, pages
Washington: OMICS Publishing Grouo , 2015. Vol. 4, no 1, 1000178
National Category
Health Sciences
Identifiers
URN: urn:nbn:se:miun:diva-23685DOI: 10.4172/2327-5162.1000178OAI: oai:DiVA.org:miun-23685DiVA: diva2:770665
Available from: 2014-12-11 Created: 2014-12-11 Last updated: 2017-08-15Bibliographically approved

Open Access in DiVA

fulltext(406 kB)57 downloads
File information
File name FULLTEXT01.pdfFile size 406 kBChecksum SHA-512
bf549f348f5ba455a1112989d7c120e22194afcbb5d3a1deaa99051bcaffa0969befea9da2b5bead846f6209976944815c1804e4801cdd1fa3a8b3102762b473
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Jong, Miek C
By organisation
Department of Nursing Sciences
Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 57 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 134 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf