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Monte Carlo dosimetry of the eye plaque design used at the St. Erik Eye Hospital for I-125 brachytherapy
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences.
Karolinska University Hospital, Sweden.
Karolinska University Hospital, Sweden; Karolinska Institute, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.
2014 (English)In: Brachytherapy, ISSN 1538-4721, Vol. 13, no 6, 651-656 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE: At St. Erik Eye Hospital in Stockholm, Sweden, ocular tumors of apical height above 6 mm are treated with brachytherapy, using iodine-125 seeds attached to a gold alloy plaque while the treatment planning is performed assuming homogeneous water surroundings. The aim of this work was to investigate the dose-modifying effects of the plaque and the seed fixating silicone rubber glue. METHODS AND MATERIALS: The impact of the gold plaque and silicone rubber glue was studied with the Monte Carlo N-particle transport code, version 5. RESULTS: For the 2 cm most proximal to the plaque surface along the plaques central axis, the eyeball received 104.6-93.0% of the dose in all-water conditions. CONCLUSIONS: The 0.3 mm thick layer of silicone rubber glue, used for seed fixation, attenuates photons little enough to allow characteristic X-rays from the gold alloy plaque to reach the eyeball. Close to the plaque, the dose rates were higher with the plaque and glue present, than in homogeneous water conditions. This is in contrast to what has been reported for more commonly used eye plaques, demonstrating the importance of investigating the dosimetry of individual treatment systems.

Place, publisher, year, edition, pages
Elsevier , 2014. Vol. 13, no 6, 651-656 p.
Keyword [en]
Eye plaque; I-125; Dosimetry; Monte Carlo simulations; Brachytherapy; Ocular melanoma
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-112619DOI: 10.1016/j.brachy.2014.05.018ISI: 000344137000018PubMedID: 24950821OAI: diva2:769575
Available from: 2014-12-08 Created: 2014-12-05 Last updated: 2015-06-09Bibliographically approved

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Karlsson, MattiasCarlsson Tedgren, Åsa
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