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Kan fysisk aktivitet påverka längden av telomerer?
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
2014 (Swedish)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [sv]

Telomerer består av specifika DNA- sekvenser samt proteiner i de yttersta ändarna på våra kromosomer, och skyddar arvsmassan som kromosomerna innehåller. Telomerer har fått mycket uppmärksamhet i studier kring åldrande på senare tid. Detta eftersom telomerer förkortas för varje celldelning, vilket kan leda till att cellen slutar dela sig vid en viss kritisk längd. Korta telomerer har kopplats till åldersrelaterade sjukdomar som exempelvis hjärtsvikt. Fysisk aktivitet i sin tur minskar risken att drabbas av åldersrelaterade sjukdomar. Syftet med arbetet var att undersöka om det finns belägg i den vetenskapliga litteraturen för ett samband mellan fysisk aktiviet och telomerlängd hos människor. Artiklar söktes i databasen PubMed. Inklusionskriterier var att artiklarna skulle undersöka effekter på vita blodkroppar (leukocyter), samt undersöka långtidseffekter av fysisk aktivitet. Totalt nio artiklar inkluderades till den tänkta undersökningen. Åtta studiers resultat tyder på att det finns ett samband mellan fysisk aktivitet och telomerlängd, medan en av studierna inte påvisar något samband. Fysisk aktivitet av måttlig intensitet verkar bevara telomerlängd, medan inaktivitet verkar förkorta telomererna i snabbare takt. Det råder en oenighet huruvida fysisk aktivitet av tyngre intensitet påverkar telomerlängd. Mer forskning krävs för att mer konkreta slutsatser ska kunna dras.

Abstract [en]

Telomeres consist of specific sequences of DNA and proteins at the ends of our chromosomes, and protects the genetic data they hold. Lately, attention has been focused on telomeres in research related to the aging process. Telomeres shorten during every cell division, and might reach a critical level when the cell stops dividing. Short telomeres are associated with several age- related diseases, for example cardiovascular disease. Physical activity reduces the risk of many age- related diseases. The purpose of this thesis was to investigate if physical activity has an effect on human telomeres. This was done by a review of the scientific literature. The database PubMed was used to search for articles. Articles in the database were included in the study if they investigated the long term effects of physical activity on telomere length in white blood cells (leukocytes). Nine articles were found that meet the inclusion criteria. The results from eight of them seems to point towards an association between psysical activity and telomere length, while one of the studies sees no such associasion. Physical activity by moderate intensity seems to protect telomeres from shortening, while inactivity seems to speed the telomere shortening process. There is some inconsistency about how high intensity of physical activity affects telomeres. More research is necessary to be able to draw further conclusions about the relationship between physical activity and telomere length.

Place, publisher, year, edition, pages
2014. , 31 p.
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:lnu:diva-38477OAI: oai:DiVA.org:lnu-38477DiVA: diva2:768031
Subject / course
Biomedical Sciences
Educational program
Health Science Programme with Specialisation in Bio Sciences, 180 credits
Supervisors
Examiners
Available from: 2015-02-20 Created: 2014-12-02 Last updated: 2015-02-20Bibliographically approved

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