Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Prostate Cancer, Prostate Cancer Death, and Death from Other Causes, Among Men with Metabolic Aberrations
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology.
Show others and affiliations
2014 (English)In: Epidemiology, ISSN 1044-3983, E-ISSN 1531-5487, Vol. 25, no 6, 823-828 p.Article in journal (Refereed) Published
Abstract [en]

Background: Few previous studies of metabolic aberrations and prostate cancer risk have taken into account the fact that men with metabolic aberrations have an increased risk of death from causes other than prostate cancer. The aim of this study was to calculate, in a real-life scenario, the risk of prostate cancer diagnosis, prostate cancer death, and death from other causes.

Methods: In the Metabolic Syndrome and Cancer Project, prospective data on body mass index, blood pressure, glucose, cholesterol, and triglycerides were collected from 285,040 men. Risks of prostate cancer diagnosis, prostate cancer death, and death from other causes were calculated by use of competing risk analysis for men with normal (bottom 84%) and high (top 16%) levels of each factor, and a composite score.

Results: During a mean follow-up period of 12 years, 5,893 men were diagnosed with prostate cancer, 1,013 died of prostate cancer, and 26,328 died of other causes. After 1996, when prostate-specific antigen testing was introduced, men up to age 80 years with normal metabolic levels had 13% risk of prostate cancer, 2% risk of prostate cancer death, and 30% risk of death from other causes, whereas men with metabolic aberrations had corresponding risks of 11%, 2%, and 44%.

Conclusions: In contrast to recent studies using conventional survival analysis, in a real-world scenario taking risk of competing events into account, men with metabolic aberrations had lower risk of prostate cancer diagnosis, similar risk of prostate cancer death, and substantially higher risk of death from other causes compared with men who had normal metabolic levels.

Place, publisher, year, edition, pages
2014. Vol. 25, no 6, 823-828 p.
National Category
Environmental Health and Occupational Health Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-96605DOI: 10.1097/EDE.0000000000000174ISI: 000343122000006PubMedID: 25207955OAI: oai:DiVA.org:umu-96605DiVA: diva2:766740
Available from: 2014-11-28 Created: 2014-11-24 Last updated: 2017-12-05Bibliographically approved

Open Access in DiVA

fulltext(596 kB)178 downloads
File information
File name FULLTEXT02.pdfFile size 596 kBChecksum SHA-512
9fbee3969552938e66a95129bb0b63fd1109b1d32c5cbbf1bf70aeca7d80af7d8f85945c80001f6e1fdf888223c7058190caeaba30f3bfdf1d5441060a370890
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Häggström, ChristelStocks, TanjaHallmans, GöranJonsson, HåkanStattin, Pär
By organisation
Urology and AndrologyNutritional ResearchDepartment of Biobank ResearchDepartment of Radiation Sciences
In the same journal
Epidemiology
Environmental Health and Occupational HealthCancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 178 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 271 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf