Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Physiology and impact of horizontal connections in rat neocortex
University of California Berkeley, USA.
Bernstein Center Freiburg, Germany and University of Freiburg, Germany.ORCID iD: 0000-0002-8044-9195
University of Freiburg, Germany.
University of Freiburg, Germany.
Show others and affiliations
2014 (English)In: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199Article in journal (Refereed) Published
Abstract [en]

Cortical information processing at the cellular level has predominantly been studied in local networks, which are dominated by strong vertical connectivity between layers. However, recent studies suggest that the bulk of axons targeting pyramidal neurons most likely originate from outside this local range, emphasizing the importance of horizontal connections. We mapped a subset of these connections to L5B pyramidal neurons in rat somatosensory cortex with photostimulation, identifying intact projections up to a lateral distance of 2 mm. Our estimates of the spatial distribution of cells presynaptic to L5B pyramids support the idea that the majority is located outside the local volume. The synaptic physiology of horizontal connections does not differ markedly from that of local connections, whereas the layer and cell-type-dependent pattern of innervation does. Apart from L2/3, L6A provides a strong source of horizontal connections. Implementing our data into a spiking neuronal network model shows that more horizontal connections promote robust asynchronous ongoing activity states and reduce noise correlations in stimulus-induced activity.

Place, publisher, year, edition, pages
Oxford University Press, 2014.
Keyword [en]
cortical network, horizontal connections, laser uncaging, noise correlation, pyramidal neuron
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:kth:diva-156082DOI: 10.1093/cercor/bhu265OAI: oai:DiVA.org:kth-156082DiVA: diva2:764707
Note

QC 20141204

Available from: 2014-11-20 Created: 2014-11-20 Last updated: 2017-12-05Bibliographically approved

Open Access in DiVA

fulltext(1479 kB)1354 downloads
File information
File name FULLTEXT01.pdfFile size 1479 kBChecksum SHA-512
bb2600b39748f2a6085a9ae502ce8fe053aa89bbddc9c3d39dee3dbca6b79439bc8bb633ad8fa73662bba46f3856eacdf09131798772d44dc2c722d10ce66163
Type fulltextMimetype application/pdf

Other links

Publisher's full textArticle at Publisher's website

Search in DiVA

By author/editor
Kumar, Arvind
In the same journal
Cerebral Cortex
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 1354 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 42 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf