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Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical pharmacogenomics and osteoporosis. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-6368-2622
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
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2014 (English)In: Clinical Pharmacology and Therapeutics, ISSN 0009-9236, E-ISSN 1532-6519, Vol. 96, no 4, 477-481 p.Article, review/survey (Refereed) Published
Abstract [en]

Angioedema is a potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. To study the genetic etiology of this rare adverse event, international consortia and multicenter recruitment of patients are needed. To reduce patient heterogeneity, we have standardized the phenotype. In brief, it comprises swelling in the head and neck region that first occurs during treatment. It should not coincide with urticaria or have another likely cause such as hereditary angioedema.

Place, publisher, year, edition, pages
2014. Vol. 96, no 4, 477-481 p.
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Pharmacology and Toxicology
URN: urn:nbn:se:uu:diva-236046DOI: 10.1038/clpt.2014.138ISI: 000342675400026OAI: diva2:764294
Swedish Research Council, 523-2008-5568
Available from: 2014-11-18 Created: 2014-11-12 Last updated: 2016-02-22Bibliographically approved

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Wadelius, MiaNordang, LeifKarawajczyk, MalgorzataHallberg, Pär
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Clinical pharmacogenomics and osteoporosisScience for Life Laboratory, SciLifeLabOtolaryngology and Head and Neck SurgeryBiochemial structure and function
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